Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD [Protective effects of hypoxia-inducible factor-1 alpha on myocardial ischemia/reperfusion injury in rat and the role of protein kinase C in signal pathway]. 20170615

2010

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD [Effects of hydrogen-rich saline on endoplasmic reticulum stress during myocardial ischemia-reperfusion in rats]. 25547710

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart. 18390819

2008

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo. 23531454

2013

Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Effects of landiolol on mechanical and metabolic changes in rat reperfused ischaemic hearts. 17201736

2007

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Biomarker RGD Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection. 21844074

2011

Entrez Id: 4973
Gene Symbol: OLR1
OLR1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.210 Therapeutic RGD LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation. 12384456

2002

Entrez Id: 5733
Gene Symbol: PTGER3
PTGER3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Therapeutic RGD Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat. 10193764

1999

Entrez Id: 1889
Gene Symbol: ECE1
ECE1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. 18586023

2008

Entrez Id: 7010
Gene Symbol: TEK
TEK
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. 12737621

2003

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Radionuclide imaging of angiotensin II type 1 receptor upregulation after myocardial ischemia-reperfusion injury. 21078800

2010

Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R. 18636044

2009

Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD MicroRNA-15b deteriorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating Bcl-2 and MAPK3. 28814571

2018

Entrez Id: 1889
Gene Symbol: ECE1
ECE1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Up-regulation of endothelin-converting-enzyme mRNA expression following cardioplegic arrest. 12193087

2002

Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Therapeutic RGD Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death. 27129213

2016

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Isoflurane preconditioning confers cardioprotection by activation of ALDH2. 23468836

2013

Entrez Id: 6839
Gene Symbol: SUV39H1
SUV39H1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Therapeutic RGD Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats. 24752040

2014

Entrez Id: 2919
Gene Symbol: CXCL1
CXCL1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. 11342480

2001

Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Therapeutic RGD LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats. 24129401

2014

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Therapeutic RGD 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. 22179023

2012

Entrez Id: 10019
Gene Symbol: SH2B3
SH2B3
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. 25628389

2015

Entrez Id: 5333
Gene Symbol: PLCD1
PLCD1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Identification of the changes in phospholipase C isozymes in ischemic-reperfused rat heart. 12623065

2003

Entrez Id: 2920
Gene Symbol: CXCL2
CXCL2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Biomarker RGD Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. 11342480

2001

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Therapeutic RGD Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I/R) injury. 23629152

2013

Entrez Id: 291
Gene Symbol: SLC25A4
SLC25A4
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Therapeutic RGD The effect of 17-methoxyl-7-hydroxy-benzene-furanchalcone on NF-κB and the inflammatory response during myocardial ischemia reperfusion injury in rats. 24126566

2014