Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.340 Biomarker PSYGENET Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats. 21414930

2011

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. 19025226

2008

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens. 22785313

2012

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.320 Biomarker PSYGENET Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. 18690111

2008

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. 18690111

2008

Entrez Id: 3620
Gene Symbol: IDO1
IDO1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. 22751107

2012

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.320 Biomarker PSYGENET CACNA1C risk variant affects reward responsiveness in healthy individuals. 25290268

2014

Entrez Id: 57030
Gene Symbol: SLC17A7
SLC17A7
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors. 22707231

2012

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. 21917807

2011

Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping. 21946917

2012

Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: a rat model of post-stroke depression. 19896211

2009

Entrez Id: 478
Gene Symbol: ATP1A3
ATP1A3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Decreased neuronal Na+, K+ -ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress. 21418141

2011

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. 17675407

2007

Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Effects of chemokine receptor signalling on cognition-like, emotion-like and sociability behaviours of CCR6 and CCR7 knockout mice. 24333375

2014

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Effects of chemokine receptor signalling on cognition-like, emotion-like and sociability behaviours of CCR6 and CCR7 knockout mice. 24333375

2014

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone. 22265242

2012

Entrez Id: 2697
Gene Symbol: GJA1
GJA1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats. 22189291

2012

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.320 Biomarker PSYGENET Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats. 10915835

2000

Entrez Id: 57030
Gene Symbol: SLC17A7
SLC17A7
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. 19409534

2009

Entrez Id: 6507
Gene Symbol: SLC1A3
SLC1A3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1. 19409534

2009

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness. 22094432

2012

Entrez Id: 5309
Gene Symbol: PITX3
PITX3
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism. 24480473

2014

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.300 Biomarker PSYGENET Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice. 20620876

2010

Entrez Id: 9869
Gene Symbol: SETDB1
SETDB1
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.310 Biomarker PSYGENET Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. 20505083

2010

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0178417
Disease: Anhedonia
Anhedonia
0.320 Biomarker PSYGENET The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. 21676128

2011