Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Biomarker RGD Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. 11934844

2002
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.500 Biomarker RGD Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. 15036620

2004
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Activation of caspase 8 in the pituitaries of streptozotocin-induced diabetic rats: implication in increased apoptosis of lactotrophs. 15976052

2005
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0243026
Disease: Sepsis
Sepsis 		0.210 Biomarker RGD Apoptotic death of renal tubular cells in experimental sepsis. 18570579

2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0014072
Disease: Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis 		0.200 Biomarker RGD Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis. 18521931

2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats. 19540304

2009
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 ModifyingMutation RGD Long-term hormonal promotion overcomes genetic resistance to mammary cancer. 20732338

2011
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain 		0.200 Biomarker RGD Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury. 23046993

2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.200 Biomarker RGD Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. 26004897

2015
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.200 Biomarker RGD Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1α and p53 pathways. 26431790

2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Biomarker RGD The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis. 27929425

2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.200 Therapeutic RGD Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl4 -induced hepatotoxicity in rats. 25447754

2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage 		0.500 Therapeutic RGD The role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH). 28096675

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0243026
Disease: Sepsis
Sepsis 		0.210 Therapeutic RGD Glutamine reduces myocardial cell apoptosis in a rat model of sepsis by promoting expression of heat shock protein 90. 29180187

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Therapeutic RGD Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats. 28843149

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.200 Therapeutic RGD Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis. 28456626

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.200 Biomarker RGD Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. 28825094

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.200 Therapeutic RGD Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. 28496315

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0027697
Disease: Nephritis
Nephritis 		0.200 Therapeutic RGD Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis through the Cascade Pathway of MEKK2-p38 MAPK-IRF-1-TRADD-Caspase 8 in Rat Thy-1 Nephritis. 28039298

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0035305
Disease: Retinal Detachment
Retinal Detachment 		0.200 Therapeutic RGD RNA Interference Reveals the Coregulatory Effects of Cylindromatosis on Apoptosis and Necroptosis of Photoreceptor Cells in Experimental Retinal Detachment. 28633009

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic 		0.200 Biomarker RGD Effect of hypothermia on apoptosis in traumatic brain injury and hemorrhagic shock model. 29061477

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies 		0.200 Therapeutic RGD H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. 28992627

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.900 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.230 Therapeutic RGD Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ 29642617

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.220 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018