Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.900 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Biomarker RGD Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. 11934844

2002
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.500 Biomarker RGD Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. 15036620

2004
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage 		0.500 Therapeutic RGD The role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH). 28096675

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.230 Therapeutic RGD Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ 29642617

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.220 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0243026
Disease: Sepsis
Sepsis 		0.210 Therapeutic RGD Glutamine reduces myocardial cell apoptosis in a rat model of sepsis by promoting expression of heat shock protein 90. 29180187

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0243026
Disease: Sepsis
Sepsis 		0.210 Biomarker RGD Apoptotic death of renal tubular cells in experimental sepsis. 18570579

2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.200 Biomarker RGD Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1α and p53 pathways. 26431790

2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.200 Biomarker RGD Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. 26004897

2015
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Therapeutic RGD Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats. 30148677

2019
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Therapeutic RGD Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats. 28843149

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats. 19540304

2009
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Activation of caspase 8 in the pituitaries of streptozotocin-induced diabetic rats: implication in increased apoptosis of lactotrophs. 15976052

2005
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.200 Therapeutic RGD Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis. 28456626

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.200 Therapeutic RGD Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NFκB, oxidative stress, and apoptosis. 29606028

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0014072
Disease: Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis 		0.200 Biomarker RGD Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis. 18521931

2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.200 Biomarker RGD Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. 28825094

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Biomarker RGD The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis. 27929425

2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.200 Biomarker RGD Similarly, the percentages of caspase-8 and -9 immunopositive cells in the IR group were higher than the IR + S group. 29748970

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.200 Biomarker RGD Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage: an experimental and immunohistochemical study. 29257007

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.200 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.200 Therapeutic RGD Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. 28496315

2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 ModifyingMutation RGD Long-term hormonal promotion overcomes genetic resistance to mammary cancer. 20732338

2011
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0027697
Disease: Nephritis
Nephritis 		0.200 Therapeutic RGD Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis through the Cascade Pathway of MEKK2-p38 MAPK-IRF-1-TRADD-Caspase 8 in Rat Thy-1 Nephritis. 28039298

2017