×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
Biomarker
LHGDN
Alterations of the p14ARF -p53-MDM2 pathway in oral squamous cell carcinoma : MDM2 overexpression is a common event.
16142358 2005
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
GeneticVariation
LHGDN
Reduced expression of the p16 protein was observed in 18 SCC (86%), while p16 gene alterations (hypermethylation (29%) and point mutation (33%)) were found in 11 (52%).
19067849 2008
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
[The expression of p53, p16, cyclin D1 in esophageal squamous cell carcinoma and esophageal dysplasia].
17060721 2006
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
Analysis of p16 expression and allelic imbalance / loss of heterozygosity of 9p21 in cutaneous squamous cell carcinomas .
16989737 2007
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
GeneticVariation
LHGDN
Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma.
16618910 2006
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
A total of 67 samples of tumor tissue from squamous cell carcinomas of the oral cavity, the pharynx and the larynx were analysed for an inactivation of p16 .
15197677 2004
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
PosttranslationalModification
LHGDN
Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only.
19148529 2009
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
Biomarker
LHGDN
Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas.
17549378 2007
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
GeneticVariation
LHGDN
This is the first description of specific abnormalities in tumor suppressor genes in RDEB associated SCC , and demonstrates that alterations in both p53 and p16ink4a can contribute to RDEB associated SCC .
15373786 2004
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
PosttranslationalModification
LHGDN
Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa.
16791592 2006
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
Biomarker
LHGDN
(v) The expression levels of SEI-1 and p16 were compared in 32 tumor specimens of human squamous cell carcinomas of the head and neck.
16201750 2005
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
Inactivation of p16 gene in histologically normal bronchi could aid the identification of individuals at risk of developing SCC of the lung.
18315600 2008
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
PosttranslationalModification
LHGDN
Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma.
17094449 2006
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue.15930346 2005
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas .
17017004 2006
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
GeneticVariation
LHGDN
Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma .
19101490 2009
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
p16INK4A in oral squamous cell carcinomas --a correlation with biological behaviors: immunohistochemical and FISH analysis.17052587 2006
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
17198740 2007
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity.
12738984 2003
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
Biomarker
LHGDN
Disrupted Rb pathway (loss of expression of RB1 and/or of CDKN2A ) in 55.9% of analysed cases confirmed the hypothesis that RB1 pathway is altered in head and neck squamous cell carcinomas , with CDKN2A (45%), rather than RB1 (11.8%) being more frequently inactivated.
15083191 2004
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
Overexpression of CyclinD1 and underexpression of p16 correlate with lymph node metastases in laryngeal squamous cell carcinoma in Chinese patients.
18787961 2008
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
The aim of our study was to analyze the relationship between genetic changes leading to inactivation of the CDKN2A gene and subsequent alteration of protein expression in squamous cell cancer of the larynx (SCCL) in connection with the clinical and histopathological course of the disease.
14991744 2004
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
GeneticVariation
LHGDN
High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population.
14732922 2004
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
GeneticVariation
LHGDN
The aim of this study was to investigate the role of human papillomaviruses (HPVs) and alterations of p16INK4A in different squamous cell carcinomas (SCC s) of the head and neck region by screening these carcinomas for alterations in exon 2 of p16INK4A and for HPV DNA.
17340131 2007
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Squamous cell carcinoma
0.700
AlteredExpression
LHGDN
Twenty percent of in situ squamous cell carcinomas had moderate to strong staining in only the lower half to lower two thirds of the epidermis, whereas 70% of the in situ squamous cell carcinomas exhibited full-thickness p16 staining, with no staining in the dermis.
12429789 2002