Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD "Endocrine pancreatic cells of postnatal ""diabetes"" (db) mice in cell culture." 393618

1979
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD A new mutation (db3J) at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization. 6993269

1980
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD A reproductive endocrine profile in the diabetes (db) mutant mouse. 378276

1979
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. 29551634

2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. 12540618

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Anti-pancreatic immunity in genetically diabetic mice. 6339122

1983
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. 9299565

1997
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. 8177042

1994
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Conditioned taste aversion learning in leptin-receptor-deficient db/db mice. 12932425

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. 15885672

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. 15685168

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Description of a new model of genetic obesity: the dbPas mouse. 3882910

1985
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Diabetes, a new mutation in the mouse. 5918576

1966
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Diabetes-induced, progressive endometrial involution characterization of periluminal epithelial lipoatrophy. 12502493

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Diabetic neuropathy in the mutant mouse [C57BL/ks(db/db)]: a morphometric study. 6991317

1980
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice. 12136396

2002
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 12885755

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. 15070774

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. 16971655

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) that causes obesity and diabetes results in increased IOP. 11532192

2001
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. 12150780

2002
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. 16443782

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Lepr(db/db) mice are obese due to a defect in the signaling portion of the leptin receptor, which has led to extensive study of this highly conserved system over the past several years. 15389315

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta. 16522636

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. 15207242

2004