Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 AlteredExpression LHGDN Aberrant p53 expression correlates with expression of vascular endothelial growth factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell lung cancer. 11844810

2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN A link between the p53 germ line polymorphisms and white blood cells apoptosis in lung cancer patients. 11844595

2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Prognostic significance of mutant p53 protein, P-glycoprotein and glutathione S-transferase-pi in patients with unresectable non-small cell lung cancer. 12926120

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer. 14566828

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis. 12169206

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN [Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]. 14761400

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN p53 status and its in vitro relationship to radiosensitivity and chemosensitivity in lung cancer. 12820372

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 AlteredExpression LHGDN Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis. 14676844

2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 AlteredExpression LHGDN Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53. 15202001

2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer. 15067062

2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN TP53 mutation, allelism and survival in non-small cell lung cancer. 15905205

2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer. 15814626

2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 AlteredExpression LHGDN Y-box-binding protein-1 expression is not correlated with p53 expression but with proliferating cell nuclear antigen expression in non-small cell lung cancer. 16101161

2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. 16287156

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer. 17409824

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN The aim of the study was to investigate a relation between p53 and HER2/neu expression in resected lung tumors and the response of those tumors to neoadjuvant chemotherapy. 16847810

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair. 17030796

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Increased risk of non-small cell lung cancer and frequency of somatic TP53 gene mutations in Pro72 carriers of TP53 Arg72Pro polymorphism. 16499995

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Clinical significance of the p53 pathway and associated gene therapy in non-small cell lung cancers. 17280505

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history. 17575133

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN p53 regulates cellular responses to environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide in human lung cancer cells. 17630511

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN Radiosensitization dependent on p53 function in bronchial carcinoma cells by the isoflavone genistein and estradiol in vitro. 17406801

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 Biomarker LHGDN P53 and MDM2 isoforms in blood from lung cancer patients. 17620186

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 GeneticVariation LHGDN Clonality and prognostic implications of p53 and epidermal growth factor receptor somatic aberrations in multiple primary lung cancers. 17200338

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.800 AlteredExpression LHGDN Apoptotic markers p53, Bcl-2 and Bax in primary lung cancer. 17091766

2007