×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
1.The epsilon 4 allele of the apolipoprotein E gene increases the risk of late onset familial and sporadic Alzheimer disease .
16758323 2007
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
LHGDN
Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia.14739533 2004
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Apolipoprotein e genotype modifies the phenotype of Alzheimer disease .16401755 2006
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
APOE genotype and cholesterol levels in lewy body dementia and Alzheimer disease : investigating genotype-phenotype effect on disease risk.16956959 2006
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
LHGDN
APOE epsilon 4 may influence rate of cognitive decline most significantly in the earliest stages of Alzheimer disease .18401023 2008
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele.
18439297 2008
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
A SAGE study of apolipoprotein E3 /3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease .
17822919 2007
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Accelerated memory decline in Alzheimer's disease with apolipoprotein epsilon4 allele.
12928512 2003
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?
16606914 2006
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Although confirmation is required, these findings suggest that HFE mutations are associated with increased oxidative stress and Braak stage, and that HFE and APOE genotypes are different between AD patients, high pathology and low pathology controls.
12707938 2003
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
LHGDN
Although the mechanisms underlying apoE4 's action in AD pathogenesis are still poorly understood, emerging data strongly suggest that apoE4 contributes to this disease by interacting with different factors through various pathways.
16432152 2006
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease .
15519745 2004
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain.
11920850 2002
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
ApoE epsilon4 allele is associated with incidental hallucinations and delusions in patients with AD.
15452311 2004
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
APOE genotype and survival in men and women with Alzheimer's disease.
11940690 2002
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
LHGDN
APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study.
15596614 2004
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms (2384G>A and 1882G>A) with Alzheimer's disease.
16480703 2006
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Apolipoprotein E epsilon 4 allele frequency in demented and cognitively impaired patients with and without cerebrovascular disease.
12417380 2002
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis.
12107813 2002
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Apolipoprotein E polymorphism and brain morphology in mild cognitive impairment.
18843182 2008
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
LHGDN
Apolipoprotein E4 (apoE4 ) is a risk factor for developing AD at an earlier age and might contribute to this effect.
17710250 2007
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Association between the APOE genotype and psychopathologic symptoms in Alzheimer's disease .
11971084 2002
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
LHGDN
Because the structural and biophysical properties of a protein determine how it functions under normal and abnormal conditions, apoE4 , with its multiple cellular origins and multiple structural and biophysical properties, might contribute to the pathology of AD through several different mechanisms.
15181247 2004
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype.
18258839 2008
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
LHGDN
Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers.
17283328 2007