×
Entrez Id:
5074
Gene Symbol:
PAWR
PAWR
Alzheimer's Disease
0.070
AlteredExpression
LHGDN
Par-4 expression was enhanced, and mitochondrial dysfunction and apoptosis exacerbated, in cells expressing presenilin-1 mutations associated with early-onset inherited AD .
9701251
1998
×
Entrez Id:
5074
Gene Symbol:
PAWR
PAWR
Alzheimer's Disease
0.070
Biomarker
LHGDN
To examine the effect of Par-4 on Abeta secretion and to reconcile amyloid/apoptosis hypotheses of AD , we generated IMR-32 cell lines that overexpress Par-4 and/or its leucine zipper domain.
11278808
2001
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
We conclude that the APP locus may predispose to AD in the very elderly.
11500807
2001
×
Entrez Id:
1129
Gene Symbol:
CHRM2
CHRM2
Alzheimer's Disease
0.030
Biomarker
LHGDN
Psychosis of Alzheimer's disease is associated with elevated muscarinic M2 binding in the cortex.
11552008
2001
×
Entrez Id:
7447
Gene Symbol:
VSNL1
VSNL1
Alzheimer's Disease
0.490
PosttranslationalModification
LHGDN
These results raise the possibility that the observed reduction in VILIP-1 -expressing cells may indicate a selective vulnerability of these neurons and that the calcium sensor protein is involved in the pathophysiology of Alzheimer's disease .
11592857
2001
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
Alzheimer's Disease
0.600
GeneticVariation
LHGDN
beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
11744168
2001
×
Entrez Id:
1139
Gene Symbol:
CHRNA7
CHRNA7
Alzheimer's Disease
0.400
AlteredExpression
LHGDN
Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease.
11771745
2001
×
Entrez Id:
1141
Gene Symbol:
CHRNB2
CHRNB2
Alzheimer's Disease
0.340
AlteredExpression
LHGDN
Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease.
11771745
2001
×
Entrez Id:
1137
Gene Symbol:
CHRNA4
CHRNA4
Alzheimer's Disease
0.100
AlteredExpression
LHGDN
The protein levels of neuronal nAChR alpha and beta subunits in human postmortem brain samples (frontal cortex and cerebellum) of control, adult DS, and AD were investigated by making use of western blot analysis.
11771745
2001
×
Entrez Id:
1136
Gene Symbol:
CHRNA3
CHRNA3
Alzheimer's Disease
0.020
AlteredExpression
LHGDN
Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease.
11771745
2001
×
Entrez Id:
7001
Gene Symbol:
PRDX2
PRDX2
Alzheimer's Disease
0.050
AlteredExpression
LHGDN
Protein levels of Prx-I and Prx-II were significantly increased in AD and DS.
11771746
2001
×
Entrez Id:
5052
Gene Symbol:
PRDX1
PRDX1
Alzheimer's Disease
0.040
AlteredExpression
LHGDN
Protein levels of Prx-I and Prx-II were significantly increased in AD and DS.
11771746
2001
×
Entrez Id:
10935
Gene Symbol:
PRDX3
PRDX3
Alzheimer's Disease
0.010
AlteredExpression
LHGDN
Decreased protein levels of Prx-III could be caused by mitochondrial damage shown in AD and DS.
11771746
2001
×
Entrez Id:
10776
Gene Symbol:
ARPP19
ARPP19
Alzheimer's Disease
0.010
AlteredExpression
LHGDN
We subsequently determined protein levels of ARPP-19 in temporal cortex and cerebellum by immunoblotting and observed significant reduction of ARPP-19 in DS (temporal cortex) and AD (cerebellum).
11771749
2001
×
Entrez Id:
3925
Gene Symbol:
STMN1
STMN1
Alzheimer's Disease
0.020
AlteredExpression
LHGDN
We suggest that the decreased protein level of stathmin in brains is associated with tangle formation and microtubule instability in DS as well as AD , but stathmin is not involved in the abnormal development of fetal DS brain.
11771751
2001
SERPINA3
Alzheimer's Disease
0.100
GeneticVariation
LHGDN
A25G and G39A substitutions in the AACT gene are probably one of the risk factors to AD in Han Chinese.
11798857
2001
×
Entrez Id:
341
Gene Symbol:
APOC1
APOC1
Alzheimer's Disease
0.500
Biomarker
LHGDN
Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease.
11825674
2002
×
Entrez Id:
4137
Gene Symbol:
MAPT
MAPT
Alzheimer's Disease
0.700
Biomarker
LHGDN
[Recent advances in Alzheimer's disease].
11831025
2001
×
Entrez Id:
9546
Gene Symbol:
APBA3
APBA3
Alzheimer's Disease
0.030
Biomarker
LHGDN
[Recent advances in Alzheimer's disease].
11831025
2001
×
Entrez Id:
351
Gene Symbol:
APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease.
11831556
2002
×
Entrez Id:
4137
Gene Symbol:
MAPT
MAPT
Alzheimer's Disease
0.700
Biomarker
LHGDN
CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease .
11831556
2002
×
Entrez Id:
4968
Gene Symbol:
OGG1
OGG1
Alzheimer's Disease
0.100
AlteredExpression
LHGDN
Immunoreactivity to hOGG1-2a is associated with neurofibrillary tangles, dystrophic neurites and reactive astrocytes in AD .
11837743
2002
×
Entrez Id:
4137
Gene Symbol:
MAPT
MAPT
Alzheimer's Disease
0.700
PosttranslationalModification
LHGDN
Microtubule associated protein tau is abnormally phosphorylated in Alzheimer's disease (AD ) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs).
11837744
2002
×
Entrez Id:
4543
Gene Symbol:
MTNR1A
MTNR1A
Alzheimer's Disease
0.020
Biomarker
LHGDN
Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients.
11841602
2002
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
Alzheimer's Disease
0.600
Biomarker
LHGDN
Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
11847218
2002