×
Entrez Id: 7024
Gene Symbol: TFCP2
TFCP2
Alzheimer's Disease
0.080
AlteredExpression
LHGDN
(4) The virtual screen identified CP2/LBP-1c/LSF as a factor that likely mediates enhanced transcription of GARS-AIRS-GART in DS-related AD .
17902044 2007
×
Entrez Id: 2618
Gene Symbol: GART
GART
Alzheimer's Disease
0.010
AlteredExpression
LHGDN
(4) The virtual screen identified CP2/LBP-1c/LSF as a factor that likely mediates enhanced transcription of GARS-AIRS-GART in DS-related AD .
17902044 2007
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
1.The epsilon 4 allele of the apolipoprotein E gene increases the risk of late onset familial and sporadic Alzheimer disease .
16758323 2007
×
Entrez Id: 239
Gene Symbol: ALOX12
ALOX12
Alzheimer's Disease
0.010
Biomarker
LHGDN
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.
15111312 2004
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk.
18319590 2008
×
Entrez Id: 7534
Gene Symbol: YWHAZ
YWHAZ
Alzheimer's Disease
0.100
GeneticVariation
LHGDN
14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk.
18319590 2008
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Alzheimer's disease (AD ) is characterized by pathological lesions, such as senile plaques (SPs) and cerebral amyloid angiopathy (CAA), both predominantly consisting of a proteolytic cleavage product of the amyloid-beta precursor protein (APP ), the amyloid-beta peptide (Abeta).16485107 2006
×
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
Alzheimer's Disease
0.700
PosttranslationalModification
LHGDN
Microtubule associated protein tau is abnormally phosphorylated in Alzheimer's disease (AD ) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs).11837744 2002
×
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
Alzheimer's Disease
0.700
Biomarker
LHGDN
ADAM10 is expressed in platelets.A reduced level of ADAM10 is observed in platelets obtained from AD patients compared to age-matched controls.12080182 2002
×
Entrez Id: 1636
Gene Symbol: ACE
ACE
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
ACE genotypes associated with the risk of AD , but II genotype as risk genetic factor only restricted in subjects with high blood pressure.12362316 2002
×
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
Alzheimer's Disease
0.050
AlteredExpression
LHGDN
TIMP-1 and TIMP-2) in CSF samples from patients with Parkinson's Disease (PD), Huntington's Disease (HD), AD and ALS as compared to age-matched control patients.12614934 2003
×
Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2
Alzheimer's Disease
0.030
Biomarker
LHGDN
TIMP-2 was significantly increased in CSF of AD and HD patients.12614934 2003
×
Entrez Id: 4241
Gene Symbol: MELTF
MELTF
Alzheimer's Disease
0.040
AlteredExpression
LHGDN
Melanotransferrin was also present in saliva and at a high level in urine, but contents were similar in controls and patients with Alzheimer's disease .12809550 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Amyloid precursor protein (APP ) and the biology of proteolytic processing: relevance to Alzheimer's disease .12824062 2003
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
Biomarker
LHGDN
Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia.14739533 2004
×
Entrez Id: 3416
Gene Symbol: IDE
IDE
Alzheimer's Disease
0.600
GeneticVariation
LHGDN
Insulin-degrading enzyme and Alzheimer disease : a genetic association study in the Han Chinese.15277615 2004
×
Entrez Id: 9446
Gene Symbol: GSTO1
GSTO1
Alzheimer's Disease
0.100
GeneticVariation
LHGDN
GSTO1 polymorphisms did not influence the risk of AD , but the Asp allele influenced the age at onset (p = 0.05).15623683 2004
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Alzheimer's Disease
0.400
GeneticVariation
LHGDN
Estrogen receptor -alpha splice variants in the medial mamillary nucleus of Alzheimer's disease patients: identification of a novel MB1 isoform.15755860 2005
×
Entrez Id: 1312
Gene Symbol: COMT
COMT
Alzheimer's Disease
0.100
GeneticVariation
LHGDN
Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease .16027741 2005
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
Apolipoprotein e genotype modifies the phenotype of Alzheimer disease .16401755 2006
×
Entrez Id: 1191
Gene Symbol: CLU
CLU
Alzheimer's Disease
0.500
Biomarker
LHGDN
Clusterin is a glycosylated protein, and an alteration of its glycosylation in Alzheimer's disease might influence accurate quantification in cerebrospinal fluid through interference of antibody binding to the protein.16490286 2006
MAPKAPK2
Alzheimer's Disease
0.010
Biomarker
LHGDN
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease .16774924 2006
×
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
Alzheimer's Disease
0.400
GeneticVariation
LHGDN
Prion protein gene M129 allele is a risk factor for Alzheimer's disease .16897605 2006
×
Entrez Id: 348
Gene Symbol: APOE
APOE
Alzheimer's Disease
0.700
GeneticVariation
LHGDN
APOE genotype and cholesterol levels in lewy body dementia and Alzheimer disease : investigating genotype-phenotype effect on disease risk.16956959 2006
×
Entrez Id: 5423
Gene Symbol: POLB
POLB
Alzheimer's Disease
0.040
Biomarker
LHGDN
DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.17065437 2006