Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0038586
Disease: Substance Use Disorders
Substance Use Disorders 		0.340 Biomarker CTD_human Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. 21513772

2011
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		0.340 Biomarker CTD_human Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. 21513772

2011
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0038586
Disease: Substance Use Disorders
Substance Use Disorders 		0.340 Biomarker CTD_human Chronic unpredictable stress enhances cocaine-conditioned place preference in type 1 cannabinoid receptor knockout mice. 18690112

2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		0.340 Biomarker CTD_human Chronic unpredictable stress enhances cocaine-conditioned place preference in type 1 cannabinoid receptor knockout mice. 18690112

2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0038586
Disease: Substance Use Disorders
Substance Use Disorders 		0.340 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		0.340 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.330 Biomarker CTD_human Our results point to CB1Rs as novel molecular players in ADHD, and suggest that therapeutic strategies aimed at interfering with the ECS might prove effective in this disorder. 22034972

2011
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 Biomarker CTD_human Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. 21513772

2011
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 Biomarker CTD_human Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. 21863215

2011
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 Biomarker CTD_human Cannabinoid signaling via the type 1 cannabinoid (CB1) receptor modulates the effects of drugs of abuse and the response to exposure to stressors. 18690112

2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.320 Therapeutic CTD_human Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats. 17572696

2007
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 Biomarker CTD_human Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. 11433348

2001
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.320 Biomarker CTD_human Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. 9888857

1999
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.310 Biomarker CTD_human This study was aimed at clarifying whether cannabinoid-type 1 (CB1) receptor may function as tumor-promoting or -suppressing signal in human cutaneous melanoma. 28131817

2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.310 Biomarker CTD_human Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. 21863215

2011
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0006868
Disease: Cannabis Abuse
Cannabis Abuse 		0.310 Biomarker CTD_human Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. 19016476

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker CTD_human Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. 19052543

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.310 Biomarker CTD_human Because cannabinoid receptor agonists are capable of reducing proliferation and inducing apoptosis in diverse cancer cells such as glioma, breast cancer, and melanoma, we evaluated whether CB1 is a potential drug target in rhabdomyosarcoma. 19509271

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker CTD_human Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants. 17596442

2007
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker CTD_human (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. 16314880

2006
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C4048158
Disease: Convulsions
Convulsions 		0.310 Biomarker CTD_human The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. 12954810

2003
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.310 Biomarker CTD_human The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. 12954810

2003
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.310 Biomarker CTD_human These results implicate anandamide and vascular CB1 receptors in the vasodilated state in advanced cirrhosis and indicate a novel approach for its management. 11433348

2001
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0596170
Disease: Binge eating disorder
Binge eating disorder 		0.300 Biomarker CTD_human Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats. 23072421

2013
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0013170
Disease: Drug habituation
Drug habituation 		0.300 Biomarker CTD_human Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. 21513772

2011