Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0021368
Disease: Inflammation
Inflammation 		0.520 Therapeutic CTD_human Stable reporter cell lines for peroxisome proliferator-activated receptor γ (PPARγ)-mediated modulation of gene expression. 21354099

2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0021368
Disease: Inflammation
Inflammation 		0.520 Therapeutic CTD_human Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock. 19926821

2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0021368
Disease: Inflammation
Inflammation 		0.520 Biomarker CTD_human Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock. 19926821

2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1720860
Disease: Familial Partial Lipodystrophy, Type 2
Familial Partial Lipodystrophy, Type 2 		0.520 Biomarker CTD_human Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophy. 19793595

2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Biomarker CTD_human Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats. 24433871

2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Therapeutic CTD_human Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats. 24433871

2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Biomarker CTD_human Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats. 24011919

2013
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Therapeutic CTD_human Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats. 24011919

2013
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice. 21757225

2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.500 Therapeutic CTD_human Troglitazone-activated PPARγ inhibits LPS-induced lung alveolar type II epithelial cells injuries via TNF-α. 21153920

2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Therapeutic CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1720859
Disease: Familial Partial Lipodystrophy, Type 1
Familial Partial Lipodystrophy, Type 1 		0.500 Biomarker CTD_human Clinical characteristics and efficacy of pioglitazone in a Japanese diabetic patient with an unusual type of familial partial lipodystrophy. 19793595

2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.500 Therapeutic CTD_human [Rosiglitazone enhances the anti-atherosclerotic effects of peroxisome proliferator-activated receptor gamma1 gene transfer in apolipoprotein-knock out mice]. 18269830

2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 Biomarker CTD_human In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.500 Therapeutic CTD_human Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. 16168052

2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366

2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Relationship between peroxisome proliferator-activated receptors (PPAR alpha and PPAR gamma) and endothelium-dependent relaxation in streptozotocin-induced diabetic rats. 12967931

2003
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.500 Therapeutic CTD_human Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. 11318962

2001
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1836302
Disease: Carotid Intimal Medial Thickness 1
Carotid Intimal Medial Thickness 1 		0.500 Biomarker CTD_human

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.480 Biomarker CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611

2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.400 Biomarker CTD_human Inhibition of miR-128 Abates Aβ-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells. 30328325

2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker CTD_human Editor's Highlight: PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis. 28962521

2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic CTD_human Editor's Highlight: PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis. 28962521

2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.400 Biomarker CTD_human Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system. 28182703

2017