Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.700 Biomarker CTD_mouse High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine. 12706858

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.700 Biomarker CTD_mouse Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice. 12165863

2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.600 Biomarker CTD_mouse High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine. 12706858

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.600 Biomarker CTD_mouse Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis. 11376694

2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.600 Biomarker CTD_mouse The results show that p53 (+/-) mice were sensitive to DBN treatment with respect to esophageal and bladder tumor development, with a mechanism that could be confined to early mutations of the residual p53 allele and increased cellular proliferation in the target organs. 12706858

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.600 Biomarker CTD_mouse Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis. 11376694

2001
Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 Biomarker CTD_mouse Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770

2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.600 Biomarker CTD_mouse Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. 22009531

2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.600 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_mouse Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. 19435901

2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_mouse Functional kinomics identifies candidate therapeutic targets in head and neck cancer. 25125259

2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.600 Biomarker CTD_mouse Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. 16543248

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.600 Biomarker CTD_mouse High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine. 12706858

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0018923
Disease: Hemangiosarcoma
Hemangiosarcoma 		0.600 Biomarker CTD_mouse Our data indicated that p53 and beta-catenin mutations in the o-nitrotoluene-induced hemangiosarcomas and K-ras mutations and p53 protein expression in riddelliine-induced hemangiosarcomas most likely occurred as a result of the genotoxic effects of these chemicals. 13678655

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0018923
Disease: Hemangiosarcoma
Hemangiosarcoma 		0.600 Biomarker CTD_mouse Our data indicate that K-ras, H-ras, and p53 mutations in these hemangiosarcomas most likely occurred as a result of the genotoxic effects of BD and that these mutations may play a role in the pathogenesis of BD-induced cardiac hemangiosarcomas in the B6C3F1 mouse. 10930038

2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0018923
Disease: Hemangiosarcoma
Hemangiosarcoma 		0.600 Biomarker CTD_mouse Final report on carcinogens background document for riddelliine. 20737008

2008
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.600 Biomarker CTD_mouse [The expression of AT1A receptor and its modulation by benazepril in the renal tubulointerstitial lesions induced by ureteral obstruction]. 9596920

1997
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker CTD_mouse To clearly establish a role for GSTP in lung tumorigenesis, we investigated whether deletion of the murine Gstp genes (Gstp1 and Gstp2) alters susceptibility to chemically induced lung tumors following exposure to BaP, 3-methylcholanthrene (3-MC), and urethane. 17909032

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_mouse Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. 22009531

2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_mouse However, simultaneous depletion of p53 and TAp63 led to both rapid tumour development and metastatic potential, although the incidence of metastases remained lower than that seen in mutant p53-expressing tumours. 23873029

2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_mouse Ezrin Inhibition Up-regulates Stress Response Gene Expression. 27137931

2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.600 Biomarker CTD_mouse Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. 29438700

2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth 		0.600 Biomarker CTD_mouse Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. 19435901

2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.600 Biomarker CTD_mouse Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. 16818635

2006