Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation LHGDN The association between COMT and bipolar disorder was tested by examining the allele and haplotype found to be associated with schizophrenia. 15211633

2004
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation LHGDN An attractive candidate gene for schizophrenia is the catechol-O-methyltransferase (COMT) gene, which is a modulator of dorsolateral prefrontal cortical function. 12815739

2003
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 AlteredExpression LHGDN The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia. 12799619

2003
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 AlteredExpression LHGDN Similar to our previously reported findings, a statistically significant association was found between aggressive behavior in SZ and the COMT 158 polymorphism; mean LHA scores were higher in subjects homozygous for 158Met, the low enzyme activity COMT variant (F(2,105) = 5.616, P = 0.005). 12815735

2003
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation LHGDN Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test. 12090821

2002
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation LHGDN We found a highly significant association between schizophrenia and a COMT haplotype (P=9.5x10-8). 12402217

2002
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation LHGDN Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population. 12082558

2002