Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. 18458038

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients. 17321325

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion. 18288638

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Clinical features reflect exon sites of EGFR mutations in patients with resected non-small-cell lung cancer. 17596643

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese. 17054433

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN Expression of constitutively activated EGFRvIII in non-small cell lung cancer. 12708474

2003
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. 15623594

2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers. 17455987

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. 15284455

2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer. 17922974

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer. 18478265

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN Association of the EGFR intron 1 CA repeat length with lung cancer risk. 17219440

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 Biomarker LHGDN Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer. 18381415

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. 18593984

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study. 17956637

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression. 18403609

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN EGFRvIII mutation in lung cancer correlates with increased EGFR copy number. 17203167

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer. 17932690

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler. 15837743

2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. 16322287

2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. 17486068

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN EGFR polymorphism of the kinase domain in Japanese lung cancer. 18541260

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 AlteredExpression LHGDN Epidermal growth factor receptor expression status in lung cancer correlates with its mutation. 16226114

2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Somatic mutations of the tyrosine kinase domain of epidermal growth factor receptor and tyrosine kinase inhibitor response to TKIs in non-small cell lung cancer: an analytical database. 18670300

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.600 GeneticVariation LHGDN Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer. 15788655

2005