Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3992
Gene Symbol: FADS1
FADS1
CUI: C0028754
Disease: Obesity
Obesity
0.220 Biomarker RGD Effect of simvastatin on desaturase activities in liver from lean and obese Zucker rats. 8446010

1993

Entrez Id: 3099
Gene Symbol: HK2
HK2
CUI: C0028754
Disease: Obesity
Obesity
0.520 Biomarker RGD Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats. 16555472

2006

Entrez Id: 6715
Gene Symbol: SRD5A1
SRD5A1
CUI: C0028754
Disease: Obesity
Obesity
0.200 Biomarker RGD Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats. 20098742

2010

Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker RGD Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. 22693203

2012

Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
CUI: C0028754
Disease: Obesity
Obesity
0.220 Therapeutic RGD Enhanced anti-obesity effects of complex of resistant starch and chitosan in high fat diet fed rats. 27987997

2017

Entrez Id: 4925
Gene Symbol: NUCB2
NUCB2
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats. 22641054

2012

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats. 18477764

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker RGD Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets. 21826222

2011

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0028754
Disease: Obesity
Obesity
0.240 Biomarker RGD Expression of caveolin-1 and -2 oligomers (but not monomers or caveolin-3) was increased in arterioles from obese rats. 22492718

2012

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker RGD Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. 21779089

2012

Entrez Id: 2806
Gene Symbol: GOT2
GOT2
CUI: C0028754
Disease: Obesity
Obesity
0.250 Biomarker RGD Fatty acid transport proteins chronically relocate to the transverse-tubules in muscle from obese Zucker rats but are resistant to further insulin-induced translocation. 23743348

2013

Entrez Id: 376497
Gene Symbol: SLC27A1
SLC27A1
CUI: C0028754
Disease: Obesity
Obesity
0.220 Biomarker RGD Fiber type- and fatty acid composition-dependent effects of high-fat diets on rat muscle triacylglyceride and fatty acid transporter protein-1 content. 15281014

2004

Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker RGD Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. 19325539

2009

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD Functional variability in corticosteroid receptors is a major component of strain differences in fat deposition and metabolic consequences of enriched diets in rat. 20723946

2011

Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0028754
Disease: Obesity
Obesity
0.300 Therapeutic RGD Furthermore, candesartan increased growth-regulated oncogene, transforming growth factor-beta1 and IL-18 in OZ kidneys to a level higher than LZ or untreated OZ. 20490358

2010

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker RGD Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. 23800849

2013

Entrez Id: 5019
Gene Symbol: OXCT1
OXCT1
CUI: C0028754
Disease: Obesity
Obesity
0.200 Biomarker RGD Genetic obesity affects neural ketone body utilization in the rat brain. 19219059

2009

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0028754
Disease: Obesity
Obesity
0.600 Therapeutic RGD Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin-resistant type-2 diabetes. 23731386

2013

Entrez Id: 5950
Gene Symbol: RBP4
RBP4
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD Hence, increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. 18401839

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0028754
Disease: Obesity
Obesity
0.240 Biomarker RGD Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model. 22194422

2012

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker RGD Here we investigated the role of ER alpha and ER beta in a model of nutrition induced obesity. 22230815

2012

Entrez Id: 1812
Gene Symbol: DRD1
DRD1
CUI: C0028754
Disease: Obesity
Obesity
0.210 Biomarker RGD Here, we test the hypothesis that renal dopamine D1 receptor dysfunction in obese Zucker rats is caused by oxidative stress. 15983225

2005

Entrez Id: 3934
Gene Symbol: LCN2
LCN2
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD Herein we show that the levels of LCN2 mRNA are dramatically increased in adipose tissue and liver of ob/ob mice and primary adipose cells isolated from Zucker obese rats, and thiazolidinedione administration reduces LCN2 expression. 18292240

2008

Entrez Id: 2878
Gene Symbol: GPX3
GPX3
CUI: C0028754
Disease: Obesity
Obesity
0.520 Biomarker RGD High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. 19212806

2009

Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
CUI: C0028754
Disease: Obesity
Obesity
0.520 Biomarker RGD High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. 16467659

2006