×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Diabetes Mellitus, Insulin-Dependent
0.900
SusceptibilityMutation
RGD
These findings are consistent with a role for rat Ptpn22 allelic variation within Iddm26.2 in the regulation of T cell responses, and subsequently the risk for development of T1D .
25505293 2015
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
CTD_mouse
Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice.
29420703 2018
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
MGD
Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy.
22297672 2012
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
CTD_mouse
A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
17151334 2007
×
Entrez Id: 3630
Gene Symbol: INS
INS
Diabetes Mellitus, Insulin-Dependent
0.700
Biomarker
MGD
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.
12925730 2003
×
Entrez Id: 3240
Gene Symbol: HP
HP
Diabetes Mellitus, Insulin-Dependent
0.600
Biomarker
RGD
The identification and validation of haptoglobin as a putative serum biomarker for autoimmune T1D in rats now affords us the opportunity to test the validity of this protein as a biomarker for human T1D , particularly in those situations where viral infection is believed to precede the onset of disease.
20975081 2010
×
Entrez Id: 3240
Gene Symbol: HP
HP
Diabetes Mellitus, Insulin-Dependent
0.600
Therapeutic
RGD
Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat.
20853098 2010
×
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600
Biomarker
MGD
IFN-gamma affects homing of diabetogenic T cells.
11714835 2001
×
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600
Biomarker
RGD
The role of endogenous interferon-gamma (IFN gamma) in the development of insulin-dependent diabetes mellitus (IDDM ) in diabetes-prone BB rats was evaluated.
8977415 1997
×
Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
Diabetes Mellitus, Insulin-Dependent
0.500
Biomarker
RGD
The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats.
15855338 2005
×
Entrez Id: 5644
Gene Symbol: PRSS1
PRSS1
Diabetes Mellitus, Insulin-Dependent
0.310
Biomarker
RGD
Rat trypsin: purification, radioimmunoassay and age-related serum levels in normal and spontaneously diabetic BB Wistar rats.
3833185 1985
×
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
Late developmental plasticity in the T helper 17 lineage.
19119024 2009
×
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
RGD
Type 1 diabetes is considered to be a Th1-dominant autoimmune disease, and a suppressive effect of CXCL10 neutralization on diabetes development has been reported in a cyclophosphamide-induced accelerated diabetes model through induction of beta cell proliferation.16339582 2005
×
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
RGD
Immunoregulatory role of nitric oxide in Kilham rat virus-induced autoimmune diabetes in DR-BB rats.
15240727 2004
×
Entrez Id: 2572
Gene Symbol: GAD2
GAD2
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
To investigate the role of glutamic acid decarboxylase 65 (GAD65 ) in the development of the Type 1 diabetes of non-obese diabetic (NOD) mice, we analysed and characterised NOD mice with targeted disruption of the GAD65 gene.
14676944 2004
×
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
Autoimmune diabetes is blocked in Stat4-deficient mice.
15041039 2004
×
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury.
12709397 2003
×
Entrez Id: 3382
Gene Symbol: ICA1
ICA1
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
RGD
ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide.
11751995 2002
×
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
RGD
Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.
11307180 2001
×
Entrez Id: 3565
Gene Symbol: IL4
IL4
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
Interleukin-4 deficiency does not exacerbate disease in NOD mice.
9703318 1998
×
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.
9308961 1997
×
Entrez Id: 5798
Gene Symbol: PTPRN
PTPRN
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
RGD
The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2.
7568143 1995
×
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
×
Entrez Id: 57818
Gene Symbol: G6PC2
G6PC2
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD
×
Entrez Id: 5799
Gene Symbol: PTPRN2
PTPRN2
Diabetes Mellitus, Insulin-Dependent
0.300
Biomarker
MGD