Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.500 Biomarker RGD L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease. 18707801

2010

Entrez Id: 5179
Gene Symbol: PENK
PENK
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.500 Biomarker RGD Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson's disease. 20456008

2010

Entrez Id: 84152
Gene Symbol: PPP1R1B
PPP1R1B
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Therapeutic RGD Intrastriatal injection of ionomycin profoundly changes motor response to l-DOPA and its underlying molecular mechanisms. 27771532

2017

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Therapeutic RGD Inhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. 26997328

2016

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Therapeutic RGD Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats. 25511986

2014

Entrez Id: 5999
Gene Symbol: RGS4
RGS4
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Therapeutic RGD RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease. 24969021

2014

Entrez Id: 1627
Gene Symbol: DBN1
DBN1
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia. 23241013

2013

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Therapeutic RGD mTOR inhibition alleviates L-DOPA-induced dyskinesia in parkinsonian rats. 23938307

2013

Entrez Id: 1958
Gene Symbol: EGR1
EGR1
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD Early gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: comparison with transient local inactivation. 22153973

2012

Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats. 21352823

2011

Entrez Id: 2870
Gene Symbol: GRK6
GRK6
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. 20410529

2010

Entrez Id: 1644
Gene Symbol: DDC
DDC
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD The roles of striatal serotonin and L -amino-acid decarboxylase on L-DOPA-induced Dyskinesia in a Hemiparkinsonian rat model. 20232137

2010

Entrez Id: 776
Gene Symbol: CACNA1D
CACNA1D
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD Antagonizing L-type Ca2+ channel reduces development of abnormal involuntary movement in the rat model of L-3,4-dihydroxyphenylalanine-induced dyskinesia. 18947822

2009

Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD Activation of striatal inflammatory mediators and caspase-3 is central to haloperidol-induced orofacial dyskinesia. 18590723

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD Coadministration of entacapone with levodopa attenuates the severity of dyskinesias in hemiparkinsonian rats. 16437585

2006

Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin. 7740056

1995

Entrez Id: 2752
Gene Symbol: GLUL
GLUL
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin. 6445277

1980

Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced
0.200 Biomarker RGD An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin. 6445277

1980