Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker LHGDN Leptin in nonalcoholic fatty liver disease. 18753993

2009
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 GeneticVariation LHGDN A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio. 18853997

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 AlteredExpression LHGDN Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. 18473416

2008
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.550 GeneticVariation LHGDN The genetic polymorphism of CYPIIE1 on the position of Pst I and Rsa I is related to the susceptibility of fatty liver. 14606109

2003
Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 AlteredExpression LHGDN Liver enzymes and histology in obese patients with obstructive sleep apnea. 18090161

2008
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 AlteredExpression LHGDN SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease. 18360697

2008
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 Biomarker LHGDN Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E. 18262228

2008
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 GeneticVariation LHGDN Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. 18820647

2008
Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 AlteredExpression LHGDN Persistent alanine aminotransferase elevation among the general Iranian population: prevalence and causes. 18473412

2008
Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 Biomarker LHGDN Effect of a hypocaloric diet in transaminases in nonalcoholic fatty liver disease and obese patients, relation with insulin resistance. 17766001

2008
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 GeneticVariation LHGDN In conclusion the presence of T allele of MTP-493G/T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation. 18482281

2008
Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 Biomarker LHGDN Probable NAFLD, by ALT levels, and diabetes among Filipino-American women. 17764776

2008
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 GeneticVariation LHGDN Apolipoprotein E gene polymorphism in nonalcoholic fatty liver disease. 17431774

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 GeneticVariation LHGDN Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis. 17395331

2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 Biomarker LHGDN Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? 17482764

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 Biomarker LHGDN Increased production of IL-1alpha and TNF-alpha in lipopolysaccharide-stimulated blood from obese patients with non-alcoholic fatty liver disease. 16564703

2006
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 AlteredExpression LHGDN A new transgenic rat model of hepatic steatosis and the metabolic syndrome. 15809359

2005
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.350 Biomarker LHGDN Only PAI-1 and tPA levels were also elevated in the hypertriglyceridemic FCHL patients without fatty liver (n=13). 18262228

2008
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.350 AlteredExpression LHGDN Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. 18473416

2008
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker LHGDN The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis. 19195631

2008
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 Biomarker LHGDN Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH. 18311774

2008
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 Biomarker LHGDN Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. 17006986

2006
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 AlteredExpression LHGDN Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. 15797948

2005
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 Biomarker LHGDN Adiponectin and its receptors in patients with chronic hepatitis C. 16139921

2005
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 Biomarker LHGDN Beyond insulin resistance in NASH: TNF-alpha or adiponectin? 15239085

2004