×
Entrez Id: 6336
Gene Symbol: SCN10A
SCN10A
Hyperalgesia
0.620
Biomarker
RGD
Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.
19070548 2009
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Hyperalgesia
0.600
Biomarker
RGD
Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response.
23159984 2013
×
Entrez Id: 4803
Gene Symbol: NGF
NGF
Hyperalgesia
0.600
Therapeutic
RGD
Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats.
22839415 2012
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Hyperalgesia
0.600
Biomarker
RGD
Peri-sciatic administration of recombinant rat IL-1β induces mechanical allodynia by activation of src-family kinases in spinal microglia in rats.
22265659 2012
×
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1
Hyperalgesia
0.600
Biomarker
RGD
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
21958434 2011
×
Entrez Id: 4803
Gene Symbol: NGF
NGF
Hyperalgesia
0.600
Biomarker
RGD
Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats.
18448607 2008
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Hyperalgesia
0.600
Biomarker
RGD
Anti-TNF-alpha antibody reduces pain-behavioral changes induced by epidural application of nucleus pulposus in a rat model depending on the timing of administration.
17304130 2007
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Hyperalgesia
0.600
Biomarker
RGD
Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway.
17459378 2007
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Hyperalgesia
0.600
Biomarker
RGD
The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat.
16675114 2006
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Hyperalgesia
0.600
Biomarker
RGD
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
15317861 2004
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Hyperalgesia
0.600
Biomarker
RGD
We also aimed to investigate whether celecoxib, a specific cyclooxygenase 2 (COX-2 ) inhibitor, would affect secondary hyperalgesia .
15464832 2004
×
Entrez Id: 4803
Gene Symbol: NGF
NGF
Hyperalgesia
0.600
Biomarker
RGD
Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model.
11425916 2001
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Hyperalgesia
0.580
Biomarker
RGD
Dynamic response to peripheral nerve injury detected by in situ hybridization of IL-6 and its receptor mRNAs in the dorsal root ganglia is not strictly correlated with signs of neuropathic pain.
23953943 2013
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Hyperalgesia
0.580
Biomarker
RGD
Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain.
18988309 2008
×
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
Hyperalgesia
0.570
Biomarker
RGD
Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats.
22531750 2012
×
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
Hyperalgesia
0.570
Biomarker
RGD
Expression of monocyte chemoattractant protein-1 and its induction by tumor necrosis factor receptor 1 in sensory neurons in the ventral rhizotomy model of neuropathic pain.
21712071 2011
×
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
Hyperalgesia
0.570
Biomarker
RGD
Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats.
18419759 2008
×
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
Hyperalgesia
0.570
Biomarker
RGD
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.
18954467 2008
×
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
Hyperalgesia
0.560
Therapeutic
RGD
A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
24204988 2013
×
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
Hyperalgesia
0.560
Biomarker
RGD
P2X3 and P2X2/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE₂ or dopamine.
20868656 2010
×
Entrez Id: 796
Gene Symbol: CALCA
CALCA
Hyperalgesia
0.540
Biomarker
RGD
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
21958434 2011
×
Entrez Id: 199
Gene Symbol: AIF1
AIF1
Hyperalgesia
0.540
Biomarker
RGD
Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat.
17284346 2007
×
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
Hyperalgesia
0.520
Therapeutic
RGD
Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4.
30142543 2018
×
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
Hyperalgesia
0.520
Therapeutic
RGD
Intrathecal lentivirus-mediated transfer of interleukin-10 attenuates chronic constriction injury-induced neuropathic pain through modulation of spinal high-mobility group box 1 in rats.
24077211 2014
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Hyperalgesia
0.520
Biomarker
RGD
Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury.
23092240 2012