Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.900 Therapeutic RGD Effects of pulsed electromagnetic fields on bone mass and Wnt/β-catenin signaling pathway in ovariectomized rats. 22704852

2012
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.900 Therapeutic RGD Zuogui Pill can prevent and treat glucocorticoid-induced osteoporosis in rats by up-regulating the expression of the key signal molecules Wnt1, LRP-5 and beta-catenin in Wnt signal transduction pathway. 21977807

2011
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. 16880407

2006
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. 11851870

2002
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD Vitamin D receptor null mutant mice fed high levels of calcium are fertile. 11385068

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. 11171393

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage. 11532865

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice. 11697802

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. 11687634

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. 10746634

2000
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.700 Biomarker MGD Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. 9241280

1997
Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.600 Therapeutic RGD Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats. 23161222

2013
Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.600 Biomarker RGD The bone-protective effect of genistein in the animal model of bilateral ovariectomy: roles of phytoestrogens and PTH/PTHR1 against post-menopausal osteoporosis. 22312238

2012
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.600 Therapeutic RGD Growth hormone treatment prevents osteoporosis in uremic rats. 17647196

2007
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.600 Biomarker MGD

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.400 Biomarker RGD Etiopathogenesis of hepatic osteodystrophy in Wistar rats with cholestatic liver disease. 19424739

2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.400 Therapeutic RGD Growth hormone treatment prevents osteoporosis in uremic rats. 17647196

2007
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.400 Therapeutic RGD [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism]. 16955786

2006
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.400 Therapeutic RGD [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism]. 16955786

2006
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.400 Biomarker RGD Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. 1466160

1992
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.390 Therapeutic RGD Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis. 14600402

2003
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.300 Therapeutic RGD Our study was designed to investigate whether resveratrol, an agonist of SIRT1, could have favorable effect on osteoporosis and to explore the underlying mechanisms. 25377437

2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.300 Therapeutic RGD Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. 22555620

2013
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.300 Biomarker RGD Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats. 24250662

2013
Entrez Id: 632
Gene Symbol: BGLAP
BGLAP
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.300 Biomarker RGD Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats. 21550389

2011