×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Driver gene mutations in BRAF, EGFR, ERBB2, HRAS, KRAS , MET, NRAS, PIK3CA, STK11, and ephrin receptor genes (EPHA1-8, 10 and EPHB1-4, 6) were studied for both LAC and MM, and in BAP1, CUL1, CDKN2A, and NF2 for MM.
26463840 2016
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Driver gene mutations in BRAF , EGFR, ERBB2, HRAS, KRAS, MET, NRAS, PIK3CA, STK11, and ephrin receptor genes (EPHA1-8, 10 and EPHB1-4, 6) were studied for both LAC and MM, and in BAP1, CUL1, CDKN2A, and NF2 for MM.
26463840 2016
×
Entrez Id: 6794
Gene Symbol: STK11
STK11
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
The wild-type LKB1 -loss-mediated MZF1/MYC axis is responsible for soft-agar growth, migration and invasion in lung adenocarcinoma cells.
24793789 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.
25184679 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.
24045185 2013
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers.
22153831 2012
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
We report the case of a non-smoking 40-year-old woman, diagnosed with metastatic poorly differentiated papillary adenocarcinoma of the lung harbouring the ALK fusion gene.
22980554 2012
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
We report the case of an adenocarcinoma of the lung associated with metachronous miliary brain and lung metastases with an echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK ) gene translocation.
22999080 2012
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
We examined epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK ) in patients with adenocarcinoma of the lung to identify driver mutations.
22135231 2012
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study.
22071784 2012
×
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
ROS1 rearrangements define a unique molecular class of lung cancers.
22215748 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
We examined epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF ), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK) in patients with adenocarcinoma of the lung to identify driver mutations.
22135231 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
We examined epidermal growth factor receptor (EGFR ), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK) in patients with adenocarcinoma of the lung to identify driver mutations.
22135231 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling.
22135231 2012
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Chromosomal rearrangements leading to constitutive activation of anaplastic lymphoma receptor tyrosine kinase (ALK) define a category of lung adenocarcinomas that may be amenable to targeted therapy with the ALK inhibitor crizotinib.
22743652 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study.
22071784 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study.
22071784 2012
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Crizotinib: an anaplastic lymphoma kinase inhibitor.
21823889 2011
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Adenocarcinoma of lung (disorder)
0.700
Biomarker
CTD_human
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
20979469 2010
×
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
Adenocarcinoma of lung (disorder)
0.650
Biomarker
CTD_human
We examined epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1 ), and anaplastic lymphoma kinase (ALK) in patients with adenocarcinoma of the lung to identify driver mutations.
22135231 2012
×
Entrez Id: 4609
Gene Symbol: MYC
MYC
Adenocarcinoma of lung (disorder)
0.500
Biomarker
CTD_human
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma .27602772 2016
×
Entrez Id: 4609
Gene Symbol: MYC
MYC
Adenocarcinoma of lung (disorder)
0.500
Biomarker
CTD_human
CRISPR/Cas9-mediated repression or deletion of a constituent enhancer within the MYC-LASE region led to significant reductions in the expression of MYC and its target genes and to the impairment of anchorage-independent and clonogenic growth, consistent with an oncogenic function.
26656844 2016
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Adenocarcinoma of lung (disorder)
0.500
Biomarker
CTD_human
Gene expression analysis in the lung of the rasH2 transgenic mouse at week 4 prior to induction of malignant tumor formation by urethane and N-methylolacrylamide.
26558449 2015
×
Entrez Id: 8626
Gene Symbol: TP63
TP63
Adenocarcinoma of lung (disorder)
0.500
Biomarker
CTD_human
We also showed an association between common variation at 3q28 (TP63 , rs13314271, OR = 1.13, P = 7.22 × 10(-10)) and lung adenocarcinoma that had been previously reported only in Asians.
24880342 2014
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Adenocarcinoma of lung (disorder)
0.500
Biomarker
CTD_human
We examined epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA , v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK) in patients with adenocarcinoma of the lung to identify driver mutations.
22135231 2012