Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.520 Biomarker RGD Sildenafil and FDP-Sr attenuate diabetic cardiomyopathy by suppressing abnormal expression of myocardial CASQ2, FKBP12.6, and SERCA2a in rats. 21441944

2011

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.300 Therapeutic RGD Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes. 23453443

2013

Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.230 Therapeutic RGD [Effects of hydrogen sulfide on myocardial fibrosis and MAPK1/3 and MMP-8 expression in diabetic rats]. 25907942

2015

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.230 Therapeutic RGD Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. 22595130

2012

Entrez Id: 5465
Gene Symbol: PPARA
PPARA
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.230 Biomarker RGD Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat. 19317897

2009

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.220 Therapeutic RGD [Effects of hydrogen sulfide on myocardial fibrosis and MAPK1/3 and MMP-8 expression in diabetic rats]. 25907942

2015

Entrez Id: 5350
Gene Symbol: PLN
PLN
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.220 Biomarker RGD Combined insulin treatment and intense exercise training improved basal cardiac function and Ca(2+)-cycling proteins expression in type 1 diabetic rats. 22185592

2012

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.210 Biomarker RGD Activation of Wnt/β-catenin/GSK3β signaling during the development of diabetic cardiomyopathy. 25586361

2016

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.210 Therapeutic RGD Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes. 23453443

2013

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.210 Therapeutic RGD Antioxidant N-acetylcysteine attenuates the reduction of Brg1 protein expression in the myocardium of type 1 diabetic rats. 23853776

2013

Entrez Id: 4878
Gene Symbol: NPPA
NPPA
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.210 Therapeutic RGD Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy. 23497378

2013

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.210 Therapeutic RGD Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. 22595130

2012

Entrez Id: 846
Gene Symbol: CASR
CASR
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.210 Biomarker RGD Decrease in calcium-sensing receptor in the progress of diabetic cardiomyopathy. 22137362

2012

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.210 Therapeutic RGD β-receptor antagonist treatment prevents activation of cell death signaling in the diabetic heart independent of its metabolic actions. 21296063

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD Abnormal cannabidiol confers cardioprotection in diabetic rats independent of glycemic control. 29274332

2018

Entrez Id: 1072
Gene Symbol: CFL1
CFL1
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling. 27576917

2017

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. 28992627

2017

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. 28992627

2017

Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. 28992627

2017

Entrez Id: 100506742
Gene Symbol: CASP12
CASP12
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model. 26869403

2016

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD Levosimendan reduces myocardial damage and improves cardiodynamics in streptozotocin induced diabetic cardiomyopathy via SERCA2a/NCX1 pathway. 27058979

2016

Entrez Id: 51094
Gene Symbol: ADIPOR1
ADIPOR1
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Biomarker RGD Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy. 24669271

2014

Entrez Id: 538
Gene Symbol: ATP7A
ATP7A
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. 24927960

2014

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Biomarker RGD Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy. 24669271

2014

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD Beneficial effects of Psidium guajava leaf extract on diabetic myocardium. 21742475

2013