|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Therapeutic |
RGD |
Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism.
|
22824914 |
2012 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
RGD |
Fibre type distribution and gene expression levels of both succinate dehydrogenase and peroxisome proliferator-activated receptor-gamma coactivator-1alpha of fibres in the soleus muscle of Zucker diabetic fatty rats.
|
17158179 |
2007 |
|
PPARGC1A
|
Heart failure
|
0.600 |
Biomarker |
MGD |
|
|
|
|
PPARGC1A
|
Congestive heart failure
|
0.600 |
Biomarker |
MGD |
|
|
|
|
PPARGC1A
|
Myocardial Infarction
|
0.540 |
Biomarker |
RGD |
Herein, we reported that the relative protein levels of RIP140/PGC-1α were up-regulated in the failing hearts after chronic myocardial infarction (MI), and correlated negatively with the energy state index phosphocreatine (PCr)/ATP ratios.
|
22503866 |
2012 |
|
PPARGC1A
|
Diabetes Mellitus, Experimental
|
0.500 |
Therapeutic |
RGD |
Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes.
|
23272147 |
2012 |
|
PPARGC1A
|
Diabetes Mellitus, Experimental
|
0.500 |
Therapeutic |
RGD |
Suppression of peroxisome proliferator-activated receptor gamma-coactivator-1alpha normalizes the glucolipotoxicity-induced decreased BETA2/NeuroD gene transcription and improved glucose tolerance in diabetic rats.
|
19520786 |
2009 |
|
PPARGC1A
|
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker |
RGD |
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.
|
18270681 |
2008 |
|
PPARGC1A
|
Obesity
|
0.300 |
Therapeutic |
RGD |
Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers.
|
23256146 |
2013 |
|
PPARGC1A
|
Alzheimer's Disease
|
0.300 |
Biomarker |
RGD |
ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats.
|
22510382 |
2012 |
|
PPARGC1A
|
Huntington Disease
|
0.300 |
Biomarker |
RGD |
Metabolic and electrophysiological changes in the basal ganglia of transgenic Huntington's disease rats.
|
22813864 |
2012 |
|
PPARGC1A
|
Obesity
|
0.300 |
Biomarker |
RGD |
Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity.
|
22401878 |
2012 |
|
PPARGC1A
|
Huntington Disease
|
0.300 |
Therapeutic |
RGD |
Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.
|
21493629 |
2011 |
|
PPARGC1A
|
Metabolic Syndrome X
|
0.290 |
Biomarker |
RGD |
Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity.
|
20383225 |
2010 |
|
PPARGC1A
|
Fatty Liver
|
0.260 |
Therapeutic |
RGD |
Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet.
|
23274094 |
2013 |
|
PPARGC1A
|
Fatty Liver
|
0.260 |
Biomarker |
RGD |
The liver steatosis resulted predominantly from hypomethylation of PGC1-α, decreased binding with its partners and subsequent impaired mitochondrial fatty acid oxidation.
|
22521344 |
2012 |
|
PPARGC1A
|
Hyperglycemia
|
0.260 |
Biomarker |
RGD |
Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis.
|
22922125 |
2012 |
|
PPARGC1A
|
Hyperglycemia
|
0.260 |
Biomarker |
RGD |
Impact of hyperglycemic control on left ventricular myocardium. A molecular and cellular basic study in a diabetic rat model.
|
19367030 |
2009 |
|
PPARGC1A
|
Cardiomyopathies
|
0.250 |
Biomarker |
MGD |
|
|
|
|
PPARGC1A
|
Renal fibrosis
|
0.240 |
Biomarker |
RGD |
In summary, these data suggest that IHG-1 increases mitochondrial biogenesis by promoting PGC-1α-dependent processes, potentially contributing to the pathogenesis of renal fibrosis.
|
21784897 |
2011 |
|
PPARGC1A
|
Sepsis
|
0.230 |
Biomarker |
RGD |
Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle.
|
20647557 |
2010 |
|
PPARGC1A
|
Diabetic Retinopathy
|
0.220 |
Biomarker |
RGD |
Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.
|
22003111 |
2011 |
|
PPARGC1A
|
Diabetic Retinopathy
|
0.220 |
Biomarker |
RGD |
Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha.
|
20566666 |
2010 |
|
PPARGC1A
|
Primary biliary cirrhosis
|
0.220 |
Biomarker |
RGD |
|
|
|
|
PPARGC1A
|
Prediabetes syndrome
|
0.210 |
Biomarker |
RGD |
Using a high-energy-diet induced pre-diabetic rat model, we evaluated testicular levels of PGC-1α and its downstream targets, nuclear respiratory factors 1 (NRF-1) and 2 (NRF-2), mitochondrial transcription factor A (TFAM) and Sirt3.
|
24361842 |
2014 |