Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Therapeutic RGD Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats. 19854030

2010
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Biomarker RGD Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. 19325539

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0030193
Disease: Pain
Pain 		0.600 Biomarker RGD Our results suggest that spinal endocannabinoids and CB1 receptors on inhibitory dorsal horn interneurons act as mediators of heterosynaptic pain sensitization and play an unexpected role in dorsal horn pain-controlling circuits. 19661434

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.510 Biomarker RGD The data indicate that overall decreases in expression following SE preempt a long-lasting CB(1) receptor redistribution, and that differential responses occur within the hippocampus to initial CB(1) receptor losses. 19368833

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0020649
Disease: Hypotension
Hypotension 		0.500 Biomarker RGD These data indicate that central CB1 receptors may play an important role in the initiation of endotoxic hypotension. 19295473

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration 		0.500 Biomarker RGD Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions. 18313855

2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.220 Biomarker RGD These results broadly support the literature showing that the cardiovascular effects of cannabinoids can be exaggerated in hypertension, but highlight the involvement of non-CB(1) receptor-mediated mechanisms in the actions of anandamide. 19133994

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0003962
Disease: Ascites
Ascites 		0.200 Biomarker RGD Cannabinoid type 1 receptor antagonism delays ascites formation in rats with cirrhosis. 19208344

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0014547
Disease: Epilepsies, Partial
Epilepsies, Partial 		0.200 Biomarker RGD Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat. 19595742

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0015967
Disease: Fever
Fever 		0.200 Biomarker RGD The endogenous cannabinoid AEA induces an integrated febrile response through activation of CB(1) receptors. 19681872

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.200 Biomarker RGD Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats. 19553924

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0030920
Disease: Peptic Ulcer
Peptic Ulcer 		0.200 Biomarker RGD Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration. 19827302

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system. 19372445

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic 		0.200 Biomarker RGD In addition, we investigated the effects of a CB1R antagonist on the vascular hyporeactivity and survival rates in rats with hemorrhagic shock. 19493421

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders 		0.200 Biomarker RGD The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease. 19414037

2009
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Type 1 diabetes alters brain cannabinoid receptor expression and phosphorylation status in rats. 18401837

2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies 		0.200 Biomarker RGD Effect of cannabinoid receptor agonists on streptozotocin-induced hyperalgesia in diabetic neuropathy. 18810243

2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.200 Biomarker RGD [Role of cannabinoid receptors in regulation of cardiac tolerance to ischemia and reperfusion]. 18771032

2008
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.200 Biomarker RGD Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. 17850365

2007