Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.600 Biomarker RGD High expression of AGE and RAGE in the livers and arteries of rats with NASH may contribute to the pathogenesis of NASH and early atherosclerosis. 20835270

2010
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.500 Therapeutic RGD Intrathecal lentivirus-mediated transfer of interleukin-10 attenuates chronic constriction injury-induced neuropathic pain through modulation of spinal high-mobility group box 1 in rats. 24077211

2014
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.500 Therapeutic RGD Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain. 25014009

2014
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 Therapeutic RGD Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. 23396166

2013
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 Biomarker RGD Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. 23396166

2013
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Biomarker RGD Morpho-mechanical intestinal remodeling in type 2 diabetic GK rats--is it related to advanced glycation end product formation? 23403079

2013
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.300 Biomarker RGD Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet. 23587252

2013
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.300 Therapeutic RGD Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. 23146804

2012
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.300 Biomarker RGD Glucose degradation products result in cardiovascular toxicity in a rat model of renal failure. 20056977

2011
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.300 Therapeutic RGD The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy. 21856399

2011
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.300 Therapeutic RGD Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats. 21683770

2011
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Biomarker RGD Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats. 19735169

2009
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.300 Biomarker RGD GSPE reduced the expression of RAGE (p < 0.01) and CTGF (p < 0.01) in the kidney, which were contributing to reversal of extracellular matrix accumulation in DN. 19142024

2009
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0243026
Disease: Sepsis
Sepsis 		0.300 Therapeutic RGD Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis. 19623040

2009
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004096
Disease: Asthma
Asthma 		0.290 ModifyingMutation RGD Proteomic analysis reveals the deregulation of inflammation-related proteins in acupuncture-treated rats with asthma onset. 23304218

2012
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0004096
Disease: Asthma
Asthma 		0.290 Therapeutic RGD Proteomic analysis reveals the deregulation of inflammation-related proteins in acupuncture-treated rats with asthma onset. 23304218

2012
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.280 Biomarker RGD Benazepril, an angiotensin-converting enzyme inhibitor, alleviates renal injury in spontaneously hypertensive rats by inhibiting advanced glycation end-product-mediated pathways. 19018797

2009
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.270 Therapeutic RGD Advanced glycation end products (AGE) and the receptor for advanced glycation end products (RAGE) are closely associated with colorectal cancer progression. 22467055

2012
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.250 Biomarker RGD Combined effects of maternal inflammation and neonatal hyperoxia on lung fibrosis and RAGE expression in newborn rats. 24226635

2014
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.250 Biomarker RGD Expression and cell distribution of receptor for advanced glycation end-products in the rat cortex following experimental subarachnoid hemorrhage. 24291745

2014
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.250 Biomarker RGD These results suggest that interaction of RAGE and its ligand S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53 signaling. 19910580

2010
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0035222
Disease: Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult 		0.250 Biomarker RGD Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. 16456142

2006
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.230 Biomarker RGD RAGE is expressed in pyramidal cells of the hippocampus following moderate hypoxic-ischemic brain injury in rats. 12618340

2003
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.220 Biomarker RGD Glycated matrix up-regulates inflammatory signaling similarly to Porphyromonas gingivalis lipopolysaccharide. 22924807

2013
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.220 Biomarker RGD High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats. 22036861

2011