Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.700 Biomarker CTD_human The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. 26229107

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.640 Biomarker CTD_human

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker CTD_human The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. 26229107

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0035934
Disease: Rubinstein-Taybi Syndrome
Rubinstein-Taybi Syndrome 		0.600 Biomarker CTD_human

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.350 Biomarker CTD_human Genetic landscape of esophageal squamous cell carcinoma. 25151357

2014
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.350 Biomarker CTD_human In OSCC samples, 65% of those with deep tumour invasion (adventitia) and 63% samples with metastasis revealed p300 promoter methylation (p<0.05). p300 mRNA expression was observed in 19.0% (4/21) of methylated tumours and 58.6% (17/29) of unmethylated tumours (p = 0.005). 17965222

2007
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0025202
Disease: melanoma
melanoma 		0.320 Biomarker CTD_human Together, our data suggest that p300 HAT activity mediates critical growth regulatory pathways in tumor cells and may serve as a potential therapeutic target for melanoma and other malignancies by promoting cellular responses to DNA damaging agents that are currently ineffective against specific cancers. 23698071

2013
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.310 Biomarker CTD_human Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas. 27158780

2016
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.310 Biomarker CTD_human New significantly mutated genes included PPP3CA, DOT1L, and FTSJD1 in lung ADC, RASA1 in lung SqCC, and KLF5, EP300, and CREBBP in both tumor types. 27158780

2016
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.310 Biomarker CTD_human The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. 26229107

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.310 Biomarker CTD_human Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. 23104009

2012
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.310 Biomarker CTD_human Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. 23104009

2012
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.310 Biomarker CTD_human Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. 21822268

2011
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.310 Biomarker CTD_human Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. 21822268

2011
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0376634
Disease: Craniofacial Abnormalities
Craniofacial Abnormalities 		0.300 Biomarker CTD_human Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression. 26921506

2016
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0014518
Disease: Toxic Epidermal Necrolysis
Toxic Epidermal Necrolysis 		0.300 Biomarker CTD_human Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 25811541

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker CTD_human These results indicate that the inhibition of EP300 might be a common therapeutic mechanism between CR and RSV in adipose tissues of obese individuals. 26441656

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0038325
Disease: Stevens-Johnson Syndrome
Stevens-Johnson Syndrome 		0.300 Biomarker CTD_human Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 25811541

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.300 Biomarker CTD_human Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma. 26192917

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker CTD_human The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. 26229107

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C1274933
Disease: Drug-Induced Stevens Johnson Syndrome
Drug-Induced Stevens Johnson Syndrome 		0.300 Biomarker CTD_human Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 25811541

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C3658301
Disease: Mycoplasma-Induced Stevens-Johnson Syndrome
Mycoplasma-Induced Stevens-Johnson Syndrome 		0.300 Biomarker CTD_human Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 25811541

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C3658302
Disease: Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum 		0.300 Biomarker CTD_human Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. 25811541

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.300 Biomarker CTD_human The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. 26229107

2015
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0010606
Disease: Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma 		0.300 Biomarker CTD_human The mutational landscape of adenoid cystic carcinoma. 23685749

2013