Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.230 Biomarker RGD Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. 17083329

2007

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.210 Biomarker RGD Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. 19268536

2009

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.210 Therapeutic RGD Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. 19268536

2009

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.200 Biomarker RGD Epigenetic regulation of genes that modulate chronic stress-induced visceral pain in the peripheral nervous system. 25263804

2015

Entrez Id: 2033
Gene Symbol: EP300
EP300
Glomerulonephritis, Membranoproliferative
0.200 Therapeutic RGD Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation. 24344329

2014

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0019284
Disease: Diaphragmatic Hernia
Diaphragmatic Hernia
0.200 Biomarker RGD Downregulation of p300 gene expression in airway mesenchyme of nitrofen-induced hypoplastic lungs. 24488106

2014

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0751859
Disease: Lead Poisoning, Nervous System
Lead Poisoning, Nervous System
0.200 Biomarker RGD Epigenetic histone modification regulates developmental lead exposure induced hyperactivity in rats. 24291742

2014

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300. 23211718

2013

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0376618
Disease: Endotoxemia
Endotoxemia
0.200 Biomarker RGD Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-α gene in acute kidney injury. 23936185

2013

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Hepatocyte nuclear factor-1alpha mediated upregulation of albumin expression in focal ischemic rat brain. 22196858

2012

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.200 Therapeutic RGD Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. 22228707

2012

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.200 Therapeutic RGD Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation. 22143029

2012

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.200 Biomarker RGD Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation. 22143029

2012

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy
0.200 Biomarker RGD miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications. 21885871

2011

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0243026
Disease: Sepsis
Sepsis
0.200 Biomarker RGD Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. 20538901

2010

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C1527348
Disease: Brain Hypoxia
Brain Hypoxia
0.200 Biomarker RGD p300 expression is induced by oxygen deficiency and protects neuron cells from damage. 19103185

2009

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.200 Biomarker RGD PARP mediates structural alterations in diabetic cardiomyopathy. 18657544

2008

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.200 Biomarker RGD Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. 18413674

2008

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0018799
Disease: Heart Diseases
Heart Diseases
0.200 Biomarker RGD Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300. 18697823

2008

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.200 Biomarker RGD The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. 18292809

2008

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. 17083329

2007

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.200 Biomarker RGD Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. 17083329

2007

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.200 Biomarker RGD Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. 17083329

2007

Entrez Id: 2033
Gene Symbol: EP300
EP300
Hepatoblastoma Caused By Somatic Mutation
0.200 Biomarker RGD Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. 17083329

2007