|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker |
LHGDN |
Associations of erosive arthritis with anti-cyclic citrullinated peptide antibodies and MHC Class II alleles in systemic lupus erythematosus.
|
18085741 |
2008 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression |
LHGDN |
HLA-DRB1 gene is a mayor factor for development of SLE in Latin Americans.
|
18295738 |
2008 |
|
HLA-DRB1
|
Narcolepsy
|
0.700 |
GeneticVariation |
LHGDN |
We examined DRB1, DRB3, DRB4, DRB5, DQA1, and DQB1 in 163 patients with centrally mediated daytime sleepiness (100 with narcolepsy) and 211 Korean controls.
|
17207713 |
2007 |
|
HLA-DRB1
|
Narcolepsy
|
0.700 |
GeneticVariation |
LHGDN |
HLA-DQB1 genotyping in a family with narcolepsy-cataplexy.
|
17658488 |
2007 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
LHGDN |
The overrepresentation of TNF-308*A, LTAlpha+252*G and HLA-DRB1*03 allele carriers was found in a subgroup of sarcoidosis patients presenting with Lofgren's syndrome (LS) by comparison with the subgroup of patients without LS (NLS; phenotype frequency LS vs NLS: 68.8 vs 37.1% for TNF-308*A, 93.8 vs 66.3% for LTA+252*G and 68.8 vs 21.3% for DRB1*03).
|
15713215 |
2005 |
|
HLA-DRB1
|
Crohn Disease
|
0.700 |
GeneticVariation |
LHGDN |
A positive association between the HLA-DRB1*0103 allele and CD was detected in non-Jewish, familial cases (p = 0.0002), with risk for CD increased by 6.7 fold by the presence of an HLA-DRB1*0103 allele as compared to 1.9 fold and 19 fold by a single or two CARD15 variant alleles, respectively.
|
15046222 |
2004 |
|
HLA-DRB1
|
Narcolepsy
|
0.700 |
Biomarker |
LHGDN |
The authors demonstrated that DRB1 1501 and DQB1 0602 were susceptibility genes for narcolepsy and those who were DRB1 15 negative could not be excluded.
|
15157381 |
2004 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
Biomarker |
LHGDN |
In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS).
|
15019280 |
2004 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
LHGDN |
The SLE patients with HLA-DRB1 * 15 and controls were analyzed for either the gene originated from the paternal or the maternal side.
|
14748996 |
2003 |
|
HLA-DRB1
|
Sarcoidosis
|
0.700 |
GeneticVariation |
LHGDN |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
LHGDN |
A highly significant increase in the frequency of DRB1*1502 and DQB1*0501 was found in SLE patients compared with normal controls.
|
12028537 |
2002 |
|
HLA-DRB1
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation |
LHGDN |
We conclude that HLA class II haplotypes containing DRB1 and DQB1 alleles are strong risk factors for human SLE.
|
12145745 |
2002 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
LHGDN |
Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
|
19116921 |
2009 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
LHGDN |
Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.
|
19116923 |
2009 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
LHGDN |
HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis.
|
18799094 |
2009 |
|
HLA-DRB1
|
Multiple Sclerosis
|
0.500 |
GeneticVariation |
LHGDN |
Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex.
|
19098025 |
2009 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
LHGDN |
The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture.
|
18240241 |
2008 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
LHGDN |
HLA polymorphism and early rheumatoid arthritis in the Moroccan population.
|
18801688 |
2008 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
LHGDN |
Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis.
|
18156150 |
2008 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation |
LHGDN |
Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus.
|
18309376 |
2008 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
LHGDN |
The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis.
|
18465452 |
2008 |
|
HLA-DRB1
|
Rheumatoid Arthritis
|
0.500 |
Biomarker |
LHGDN |
Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis.
|
18240242 |
2008 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
LHGDN |
The allele frequency of HLA-DRB1*09 was significantly higher in patients with UC diagnosed at the age of 40 years or older than in those with UC diagnosed before the age of 40 years (OR=2.31, Pc=0.022).
|
18416774 |
2008 |
|
HLA-DRB1
|
Multiple Sclerosis
|
0.500 |
GeneticVariation |
LHGDN |
However, we show for the first time that HLA-DRB1*15 allele modulates the course of MS for relapsing-remitting (RR) onset patients likely by precipitating the secondary progressive (SP) phase.
|
18615093 |
2008 |
|
HLA-DRB1
|
Multiple Sclerosis
|
0.500 |
GeneticVariation |
LHGDN |
To explore whether the relative rarity of MS in Malta might be the result of lower population frequencies of major histocompatibility complex susceptibility alleles, we genotyped the HLA-DRB1 locus in 77 Maltese-born patients (97% of the prevalent unrelated native cases) and 206 Maltese controls.
|
18057318 |
2008 |