Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.700 ModifyingMutation RGD Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta. 24239160

2014
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.700 Biomarker RGD [Studies on insulin-like growth factor I receptor in fetal rats with intrauterine growth retardation]. 12536576

2001
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.560 Therapeutic RGD Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. 23562514

2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.560 Biomarker RGD While these disturbances were mostly corrected by restoring receptor function, blockade of the IGF-I receptor exacerbated AD-like pathology in old mutant mice already affected of brain amyloidosis and cognitive derangement. 16274856

2006
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.510 Biomarker RGD Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway. 19703168

2009
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.300 Biomarker RGD Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat. 18079205

2008
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.270 Biomarker RGD MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. 18986336

2009
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.270 Biomarker RGD Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes. 17476475

2007
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.230 Biomarker RGD In contrast to the proximal tubules, the distal tubular system, including glycogenotic AEL, had the same levels of enzyme activities as RCC (e.g. high glycogen phosphorylase and synthase activity, lack of glucose 6-phosphatase activity) and the same expression patterns of cytokeratin 7 and several growth factors, along with their receptors and signal transduction proteins (TGF-alpha, EGF receptor, IGF-I, IGF-I receptor, IGF-II receptor, insulin receptor substrate 1, v-raf-1 murine leukemia viral oncogene homologue 1 and mitogen activated protein kinase kinase 1). 17952403

2007
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0028754
Disease: Obesity
Obesity 		0.220 Biomarker RGD IGF-I receptor mRNA levels were significantly reduced in obese rat hearts. 11009458

2000
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.210 Biomarker RGD Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor. 21854769

2011
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.210 Biomarker RGD Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. 19008912

2008
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.210 Biomarker RGD Myocardial infarction and the myocyte IGF1 autocrine system. 8682060

1995
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C2750440
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 SusceptibilityMutation RGD Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. 24275070

2014
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 SusceptibilityMutation RGD Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. 24275070

2014
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C3150651
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2 		0.200 SusceptibilityMutation RGD Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. 24275070

2014
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.200 Biomarker RGD We examined the effects of maternal diabetes on insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (InsR) expression in the developing rat hippocampus. 22241286

2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0265706
Disease: Gastroschisis
Gastroschisis 		0.200 Biomarker RGD The role of gut-liver axis in the restriction of intrauterine growth in a model of experimental gastroschisis. 23381816

2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0024636
Disease: Malocclusion
Malocclusion 		0.200 Biomarker RGD Differential expression of IGF1, IGFR1 and IGFBP3 in mandibular condylar cartilage between male and female rats applied with malocclusion. 22758598

2012
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0085677
Disease: Alcoholic Neuropathy
Alcoholic Neuropathy 		0.200 Biomarker RGD Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance. 23016131

2012
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0005944
Disease: Metabolic Bone Disorder
Metabolic Bone Disorder 		0.200 Therapeutic RGD Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. 21567076

2011
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. 20555424

2010
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.200 ModifyingMutation RGD Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1. 18683239

2008
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0020505
Disease: Hyperphagia
Hyperphagia 		0.200 Biomarker RGD Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats. 17567960

2007
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism 		0.200 Biomarker RGD These results indicate that oxidative stress is involved in cardiac hypertrophy, and suggest a role for IGF-IR as a mediator of this adaptive response in experimental hyperthyroidism. 17447016

2007