Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C2748572
Disease: SeSAME syndrome
SeSAME syndrome 		1.000 Biomarker MGD Mutations in KCNJ10 cause a specific disorder, consisting of epilepsy, ataxia, sensorineural deafness, and tubulopathy. 19420365

2009
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C2748572
Disease: SeSAME syndrome
SeSAME syndrome 		1.000 Biomarker MGD Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit. 12618319

2003
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C2748572
Disease: SeSAME syndrome
SeSAME syndrome 		1.000 Biomarker MGD KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential. 11788352

2002
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C2748572
Disease: SeSAME syndrome
SeSAME syndrome 		1.000 Biomarker MGD Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. 11466414

2001
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C2748572
Disease: SeSAME syndrome
SeSAME syndrome 		1.000 Biomarker MGD Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. 10908613

2000
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0018784
Disease: Sensorineural Hearing Loss (disorder)
Sensorineural Hearing Loss (disorder) 		0.300 Biomarker RGD Long-lasting changes in the cochlear K+ recycling structures after acute energy failure. 23827367

2014
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.210 Biomarker RGD Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1(G93A) rat model. 22987392

2012
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0270857
Disease: Epilepsy, Reflex
Epilepsy, Reflex 		0.200 Biomarker RGD Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. 30813600

2019
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0018776
Disease: Hearing Loss, Central
Hearing Loss, Central 		0.200 Biomarker RGD Long-lasting changes in the cochlear K+ recycling structures after acute energy failure. 23827367

2014
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0018780
Disease: Hearing Loss, High-Frequency
Hearing Loss, High-Frequency 		0.200 Biomarker RGD Long-lasting changes in the cochlear K+ recycling structures after acute energy failure. 23827367

2014
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0014549
Disease: Tonic-Clonic Epilepsy
Tonic-Clonic Epilepsy 		0.200 Biomarker RGD Expressional analysis of inwardly rectifying Kir4.1 channels in Noda epileptic rat (NER). 23603404

2013
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.200 Therapeutic RGD Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology. 22143324

2012
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0035304
Disease: Retinal Degeneration
Retinal Degeneration 		0.200 Biomarker RGD The changes of potassium currents in RCS rat Müller cell during retinal degeneration. 22055109

2012
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.200 Therapeutic RGD p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage. 22420318

2012
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.200 Therapeutic RGD Expression of aquaporin 4 and Kir4.1 in diabetic rat retina: treatment with minocycline. 21672350

2011
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0035328
Disease: Retinal Vein Occlusion
Retinal Vein Occlusion 		0.200 Biomarker RGD Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. 21487926

2011
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.200 Biomarker RGD Down-regulation of Kir4.1 in the cerebral cortex of rats with liver failure and in cultured astrocytes treated with glutamine: Implications for astrocytic dysfunction in hepatic encephalopathy. 21538466

2011
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Biomarker RGD Impact of global cerebral ischemia on K+ channel expression and membrane properties of glial cells in the rat hippocampus. 20833221

2010
Entrez Id: 3766
Gene Symbol: KCNJ10
KCNJ10
CUI: C0042164
Disease: Uveitis
Uveitis 		0.200 Biomarker RGD Differential expression of Kir4.1 and aquaporin 4 in the retina from endotoxin-induced uveitis rat. 17356517

2007