Source: ORPHANET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia 		1.000 SomaticCausalMutation ORPHANET Juvenile myelomonocytic leukemia (JMML) is an intractable pediatric leukemia with poor prognosis whose molecular pathogenesis is poorly understood, except for somatic or germline mutations of RAS pathway genes, including PTPN11, NF1, NRAS, KRAS and CBL, in the majority of cases. 23832011

2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia 		1.000 SomaticCausalMutation ORPHANET Molecular basis of juvenile myelomonocytic leukemia. 20139388

2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0028326
Disease: Noonan Syndrome
Noonan Syndrome 		1.000 GermlineCausalMutation ORPHANET Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. 16773572

2006
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1275081
Disease: Cardio-facio-cutaneous syndrome
Cardio-facio-cutaneous syndrome 		0.800 GermlineCausalMutation ORPHANET The cardiofaciocutaneous syndrome. 16825433

2006
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0265329
Disease: Organoid Nevus Phakomatosis
Organoid Nevus Phakomatosis 		0.750 SomaticCausalMutation ORPHANET Mosaicism for HRAS c.37G>C and KRAS c.35G>A mutations was found in two individuals with Schimmelpenning syndrome. 22683711

2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C2674723
Disease: RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER
RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER 		0.630 SomaticCausalMutation ORPHANET Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis. 21079152

2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C3854181
Disease: Nevus sebaceous
Nevus sebaceous 		0.430 SomaticCausalMutation ORPHANET Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. 22683711

2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma 		0.400 SomaticCausalMutation ORPHANET RAS mutations in indeterminate thyroid nodules are predictive of the follicular variant of papillary thyroid carcinoma. 25109485

2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma 		0.400 SomaticCausalMutation ORPHANET Preoperative RAS mutational analysis is of great value in predicting follicular variant of papillary thyroid carcinoma. 25648502

2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma 		0.400 SomaticCausalMutation ORPHANET Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics. 25132659

2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma 		0.400 SomaticCausalMutation ORPHANET BRAF and RAS mutations in follicular variants of papillary thyroid carcinoma. 23625203

2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1333990
Disease: Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer 		0.400 Biomarker ORPHANET Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer. 19731079

2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1838329
Disease: APLASIA CUTIS CONGENITA WITH EPIBULBAR DERMOIDS
APLASIA CUTIS CONGENITA WITH EPIBULBAR DERMOIDS 		0.330 SomaticCausalMutation ORPHANET Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations. 25808193

2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0406612
Disease: Encephalocraniocutaneous lipomatosis
Encephalocraniocutaneous lipomatosis 		0.310 GeneticVariation ORPHANET Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis. 26970110

2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.310 SusceptibilityMutation ORPHANET Familial and sporadic pancreatic cancer share the same molecular pathogenesis. 25240578

2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1519086
Disease: Pilomyxoid astrocytoma
Pilomyxoid astrocytoma 		0.300 SomaticCausalMutation ORPHANET MAPK pathway activation in pilocytic astrocytoma. 22159586

2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1519086
Disease: Pilomyxoid astrocytoma
Pilomyxoid astrocytoma 		0.300 SomaticCausalMutation ORPHANET Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. 21424530

2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1112155
Disease: Hereditary non-polyposis colorectal cancer syndrome
Hereditary non-polyposis colorectal cancer syndrome 		0.300 Biomarker ORPHANET Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer. 19731079

2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1519086
Disease: Pilomyxoid astrocytoma
Pilomyxoid astrocytoma 		0.300 SomaticCausalMutation ORPHANET Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. 19373855

2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1519086
Disease: Pilomyxoid astrocytoma
Pilomyxoid astrocytoma 		0.300 SomaticCausalMutation ORPHANET Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma. 17712732

2007