Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.700 AlteredExpression LHGDN Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers. 18404969

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.700 GeneticVariation LHGDN Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome. 15533361

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.700 AlteredExpression LHGDN Plasma leptin, fatty acids, and tumor necrosis factor-receptor and insulin resistance in children. 12690082

2003
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 AlteredExpression LHGDN Serum leptin and its relationship with metabolic variables in Arabs with type 2 diabetes mellitus. 18779635

2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker LHGDN Leptin in nonalcoholic fatty liver disease. 18753993

2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 AlteredExpression LHGDN We identified significant associations between LEPTIN single nucleotide polymorphisms with blood pressure and hypertension, but in postmenopausal women only. 19204185

2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker LHGDN The influence of obesity on the oxidative stress status and the concentration of leptin in type 2 diabetes mellitus patients. 17850913

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 AlteredExpression LHGDN Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. 18473416

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker LHGDN Hyperleptinemia is associated with hypertension in Japanese males. 18596833

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker LHGDN Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. 17445536

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 GeneticVariation LHGDN [Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy]. 18050615

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker LHGDN Relationship between changes in serum leptin levels and blood pressure after weight loss. 12484512

2002
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 AlteredExpression LHGDN Familial obesity, sympathetic activation and blood pressure level. 11800057

2001
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.400 AlteredExpression LHGDN Subcutaneous and omental fat expression of adiponectin and leptin in women with polycystic ovary syndrome. 17562334

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha. 17653093

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker LHGDN Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophrenia. 17285096

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.400 Biomarker LHGDN Relationship between leptin concentration and insulin resistance. 18075970

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. 17344214

2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 AlteredExpression LHGDN Reduced brain leptin in patients with major depressive disorder and in suicide victims. 16936761

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers. 16609020

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. 16533767

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.400 Biomarker LHGDN Evidence for altered adipocyte function in polycystic ovary syndrome. 15757855

2005
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 AlteredExpression LHGDN Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. 16009333

2005
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.400 Biomarker LHGDN Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome. 15533361

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.400 Biomarker LHGDN Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. 15240518

2004