Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0023817
Disease: Hyperlipoproteinemia Type I
Hyperlipoproteinemia Type I 		1.000 Biomarker MGD Furthermore, half-normal levels of LPL cause a decrease in VLDL fractional catabolic rate and mild hypertriglyceridemia, implying that partial LPL deficiency has physiological consequences. 8675619

1995
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0023817
Disease: Hyperlipoproteinemia Type I
Hyperlipoproteinemia Type I 		1.000 Biomarker MGD Pups homozygous (-/-) for LPL deficiency died within 48 h of birth with extreme elevations of serum triglycerides (13,327 mg/dl) associated with essentially absent LPL enzyme activity in heart and carcass. 7759497

1995
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia 		0.700 Therapeutic RGD The effects of shenmai injection on body weight, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), super oxide dismutase (SOD), glutathione peroxidase(GSH-Px), malondialdehyde (MDA), the activities of lipoprotein lipase(LPL) and hepatic lipase (HL) in hyperlipidemia rats were detected. 29931882

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Therapeutic RGD Anti-obesity effects of tea from Mangifera indica L. leaves of the Ubá variety in high-fat diet-induced obese rats. 28514832

2017
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Therapeutic RGD Ubá mango juices intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats. 27160499

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Biomarker RGD The formation of obesity prone rats may be associated with decreased HSL gene expression and increased LPL gene expression, which promote adipose synthesis and inhibit lipolysis. 17712951

2007
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.600 Biomarker RGD Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. 11016888

2000
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.400 Therapeutic RGD Exercise prevents HFD- and OVX-induced type 2 diabetes risk factors by decreasing fat storage and improving fuel utilization. 29981201

2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.400 Biomarker RGD Effect of DanQi Pill on PPARα, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease. 27000070

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Therapeutic RGD Gly in MS rats decreased body weight, intra-abdominal adipose tissue, adipocyte hypertrophy, blood pressure, triglycerides, insulin, HOMA-IR index, leptin, total fatty acids, non-esterified fatty acids and LPL activity. 26996629

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0020476
Disease: Hyperlipoproteinemias
Hyperlipoproteinemias 		0.220 Therapeutic RGD [Modulating effects of shenmai injection on serum lipids in rats with hyperlipemia]. 29931882

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C2750440
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Thiazolidinedione induces a therapeutic effect on hepatosteatosis by regulating stearoyl-CoA desaturase-1, lipase activity, leptin and resistin. 30214514

2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Thiazolidinedione induces a therapeutic effect on hepatosteatosis by regulating stearoyl-CoA desaturase-1, lipase activity, leptin and resistin. 30214514

2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C3150651
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2 		0.200 Therapeutic RGD Thiazolidinedione induces a therapeutic effect on hepatosteatosis by regulating stearoyl-CoA desaturase-1, lipase activity, leptin and resistin. 30214514

2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0023896
Disease: Alcoholic Liver Diseases
Alcoholic Liver Diseases 		0.200 Therapeutic RGD Antihyperlipidemic and antiapoptotic potential of zingerone on alcohol induced hepatotoxicity in experimental rats. 28442378

2017
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Therapeutic RGD Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats. 27158912

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C2750440
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD [Preventive and therapeutic effects of compound ginkgo extract in rats with nonalcoholic steatohepatitis induced by high-fat, high-fructose diet]. 27978932

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD [Preventive and therapeutic effects of compound ginkgo extract in rats with nonalcoholic steatohepatitis induced by high-fat, high-fructose diet]. 27978932

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C3150651
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2 		0.200 Therapeutic RGD [Preventive and therapeutic effects of compound ginkgo extract in rats with nonalcoholic steatohepatitis induced by high-fat, high-fructose diet]. 27978932

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.200 Therapeutic RGD Pyrazinamide induced hepatic injury in rats through inhibiting the PPARα pathway. 27071702

2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.200 Biomarker RGD Compared to the controls, the CRF group exhibited severe hypertriglyceridemia, significant reduction of the skeletal muscle, myocardium and adipose tissue LPL mRNA and protein abundance. 22009636

2012
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5 		0.200 Biomarker RGD Lipoprotein lipase deficiency in chronic kidney disease is accompanied by down-regulation of endothelial GPIHBP1 expression. 22009636

2012
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference. 18780778

2008
Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C0017668
Disease: Focal glomerulosclerosis
Focal glomerulosclerosis 		0.200 Biomarker RGD Protein restriction and AST-120 improve lipoprotein lipase and VLDL receptor in focal glomerulosclerosis. 14531811

2003