Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0848558
Disease: Hypospadias
Hypospadias 		0.370 Biomarker CTD_human Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias. 18001166

2007
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.350 Biomarker CTD_human Forced ATF3 over expression in a prostate cancer cell line induced cell proliferation and accelerated cell cycle progression from G1 to S-phase. 16516039

2006
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.340 Biomarker CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366

2005
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.320 Therapeutic CTD_human Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes. 25136830

2014
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.320 Biomarker CTD_human Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. 17043644

2007
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0021400
Disease: Influenza
Influenza 		0.310 Biomarker CTD_human A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. 23326326

2013
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.310 Biomarker CTD_human Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes. 21159647

2010
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.310 Biomarker CTD_human They indicate that ATF3 is an androgen regulated gene that is highly expressed in prostate tumors and stimulating cell proliferation. 16516039

2006
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion 		0.310 Biomarker CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626

2002
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136

2014
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0033141
Disease: Cardiomyopathies, Primary
Cardiomyopathies, Primary 		0.300 Therapeutic CTD_human Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes. 25136830

2014
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0036529
Disease: Myocardial Diseases, Secondary
Myocardial Diseases, Secondary 		0.300 Therapeutic CTD_human Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes. 25136830

2014
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.300 Biomarker CTD_human Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes. 21159647

2010
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.300 Biomarker CTD_human Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. 18701217

2008
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.300 Biomarker CTD_human Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy. 18754875

2008
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C4721453
Disease: Peripheral Nervous System Diseases
Peripheral Nervous System Diseases 		0.300 Biomarker CTD_human Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel. 17686523

2007
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366

2005
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.300 Biomarker CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366

2005
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366

2005
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.300 Therapeutic CTD_human Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. 15674352

2005
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.300 Therapeutic CTD_human Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. 15674352

2005
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0238281
Disease: Middle Cerebral Artery Syndrome
Middle Cerebral Artery Syndrome 		0.300 Biomarker CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626

2002
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0740376
Disease: Middle Cerebral Artery Thrombosis
Middle Cerebral Artery Thrombosis 		0.300 Biomarker CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626

2002
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.300 Biomarker CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626

2002
Entrez Id: 467
Gene Symbol: ATF3
ATF3
CUI: C0751845
Disease: Middle Cerebral Artery Embolus
Middle Cerebral Artery Embolus 		0.300 Biomarker CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626

2002