Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension. 27292124

2016
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies. 25101153

2014
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker CTD_human We found that administration of nor-NOHA significantly decreased airway hyperreactivity and eosinophilic airway inflammation in ovalbumin-exposed C57BL/6 mice, but these parameters were unchanged in ovalbumin-exposed NOS2-/- mice. 19800904

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 Biomarker CTD_human Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery. 20035746

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human Serum neopterin, nitric oxide, inducible nitric oxide synthase and tumor necrosis factor-alpha levels in patients with ischemic heart disease. 18605955

2008
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 Biomarker CTD_human Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. 17138957

2007
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 Biomarker CTD_human Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats. 15631943

2005
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.570 Biomarker CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.560 Biomarker CTD_human SO2 inhalation contributes to the development and progression of ischemic stroke in the brain. 20083630

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.540 Biomarker CTD_human Inhibitory effects of ursodeoxycholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. 12620498

2003
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0009319
Disease: Colitis
Colitis 		0.530 Biomarker CTD_human Resistance to DSS-induced colitis was lost when wild-type (wt) BM was used to reconstitute iNOS-/- mice. 17449036

2007
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0009319
Disease: Colitis
Colitis 		0.530 Biomarker CTD_human Colitis and interleukin 1beta up-regulate inducible nitric oxide synthase and superoxide dismutase in rat myenteric neurons. 8698225

1996
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.510 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.500 Biomarker CTD_human Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway. 30026087

2018
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker CTD_human Resveratrol mitigates rat retinal ischemic injury: the roles of matrix metalloproteinase-9, inducible nitric oxide, and heme oxygenase-1. 23075401

2013
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker CTD_human SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI). 23061969

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Biomarker CTD_human Insulin and resveratrol act synergistically, preventing cardiac dysfunction in diabetes, but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin. 20828608

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Therapeutic CTD_human Insulin and resveratrol act synergistically, preventing cardiac dysfunction in diabetes, but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin. 20828608

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Biomarker CTD_human Effects of quercetin on gene and protein expression of NOX and NOS after myocardial ischemia and reperfusion in rabbit. 19207477

2009
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Therapeutic CTD_human Effects of quercetin on gene and protein expression of NOX and NOS after myocardial ischemia and reperfusion in rabbit. 19207477

2009
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker CTD_human Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model. 19673871

2009
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human Inhibition of inducible nitric oxide synthase activity prevents liver recovery in rat thioacetamide-induced fibrosis reversal. 18380797

2008
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. 16380483

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Therapeutic CTD_human Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. 14990356

2004