|
SERPINE1
|
Diabetic Nephropathy
|
0.600 |
Therapeutic |
RGD |
Panax notoginseng saponins protect kidney from diabetes by up-regulating silent information regulator 1 and activating antioxidant proteins in rats.
|
26712211 |
2016 |
|
SERPINE1
|
Hypertensive disease
|
0.600 |
Therapeutic |
RGD |
Thiamine attenuates the hypertension and metabolic abnormalities in CD36-defective SHR: uncoupling of glucose oxidation from cellular entry accompanied with enhanced protein O-GlcNAcylation in CD36 deficiency.
|
16645728 |
2007 |
|
SERPINE1
|
Diabetic Nephropathy
|
0.600 |
Biomarker |
RGD |
Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor.
|
15322501 |
2004 |
|
SERPINE1
|
Kidney Failure, Chronic
|
0.510 |
Therapeutic |
RGD |
An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure.
|
26903149 |
2016 |
|
SERPINE1
|
Focal glomerulosclerosis
|
0.500 |
Therapeutic |
RGD |
Shensu II Recipe could postpone the development of GS in FSGS rats possibly through inhibiting the expressions of TGF-beta1 and PAI-1, hindering the over-accumulation of mesangial matrix.
|
22303720 |
2011 |
|
SERPINE1
|
Metabolic Syndrome X
|
0.300 |
Therapeutic |
RGD |
Pioglitazone in adult rats reverses immediate postnatal overfeeding-induced metabolic, hormonal, and inflammatory alterations.
|
26084260 |
2015 |
|
SERPINE1
|
Pulmonary Fibrosis
|
0.300 |
Therapeutic |
RGD |
The present study was undertaken to examine the effects on pulmonary fibrosis of silencing PAI-1 expression with small interfering RNA (siRNA) and to assess the possible underlying mechanisms.
|
22659625 |
2012 |
|
SERPINE1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker |
RGD |
The Ayurvedic Medicine Salacia oblonga Attenuates Diabetic Renal Fibrosis in Rats: Suppression of Angiotensin II/AT1 Signaling.
|
19706694 |
2011 |
|
SERPINE1
|
Asthma
|
0.300 |
Biomarker |
RGD |
Tissue plasminogen activator activity was significantly decreased in asthmatic animals (4.48 +/- 0.4 vs. 6.7 +/- 0.3 ng/ml for OVA/OVA and OVA/VEH; p < 0.05), and PAI-1 activity was statistically significantly higher in asthma rats (0.8 +/- 0.05 vs. 0.5 +/- 0.03 ng/ml for OVA/OVA vs. OVA/VEH; p < 0.05). alpha2-Antiplasmin was higher in rats receiving OVA sensitization than in those that were sham sensitized (p < 0.05).
|
18594148 |
2008 |
|
SERPINE1
|
Myocardial Infarction
|
0.300 |
Biomarker |
RGD |
Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction.
|
16053971 |
2005 |
|
SERPINE1
|
Pulmonary Fibrosis
|
0.300 |
Biomarker |
RGD |
[Changes of coagulation and fibrinolysis system in bronchoalveolar lavage fluid in lung fibrosis].
|
16224526 |
2005 |
|
SERPINE1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Therapeutic |
RGD |
Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves blood coagulation abnormalities and dysfunction of vascular endothelial cells in Otsuka Long-Evans Tokushima fatty rats.
|
14614217 |
2003 |
|
SERPINE1
|
Sepsis
|
0.300 |
Therapeutic |
RGD |
Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis.
|
12000738 |
2002 |
|
SERPINE1
|
Diabetes Mellitus
|
0.300 |
Therapeutic |
RGD |
Long-term administration of highly purified eicosapentaenoic acid ethyl ester prevents diabetes and abnormalities of blood coagulation in male WBN/Kob rats.
|
10910004 |
2000 |
|
SERPINE1
|
Aortic Aneurysm, Abdominal
|
0.280 |
Biomarker |
RGD |
Aortic length changes during abdominal aortic aneurysm formation, expansion and stabilisation in a rat model.
|
20554458 |
2010 |
|
SERPINE1
|
Renal fibrosis
|
0.260 |
Biomarker |
RGD |
Low-dose paclitaxel ameliorates renal fibrosis by suppressing transforming growth factor-β1-induced plasminogen activator inhibitor-1 signaling.
|
26869361 |
2016 |
|
SERPINE1
|
Renal fibrosis
|
0.260 |
Therapeutic |
RGD |
Effects of Bone Marrow Mesenchymal Stem Cells on Plasminogen Activator Inhibitor-1 and Renal Fibrosis in Rats with Diabetic Nephropathy.
|
27018336 |
2016 |
|
SERPINE1
|
Glomerulosclerosis (disorder)
|
0.260 |
Biomarker |
RGD |
Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation.
|
27129290 |
2016 |
|
SERPINE1
|
Glomerulosclerosis (disorder)
|
0.260 |
Therapeutic |
RGD |
Effects of combination PPARγ agonist and angiotensin receptor blocker on glomerulosclerosis.
|
26999660 |
2016 |
|
SERPINE1
|
Cerebral Infarction
|
0.260 |
Therapeutic |
RGD |
Receptor-associated protein promotes t-PA expression, reduces PAI-1 expression and improves neurorecovery after acute ischemic stroke.
|
25702149 |
2015 |
|
SERPINE1
|
Disseminated Intravascular Coagulation
|
0.250 |
Biomarker |
RGD |
Bacillus anthracis cell wall peptidoglycan but not lethal or edema toxins produces changes consistent with disseminated intravascular coagulation in a rat model.
|
23737601 |
2013 |
|
SERPINE1
|
Disseminated Intravascular Coagulation
|
0.250 |
Therapeutic |
RGD |
Selective inducible nitric oxide synthase inhibition attenuates organ dysfunction and elevated endothelin levels in LPS-induced DIC model rats.
|
15869603 |
2005 |
|
SERPINE1
|
Endotoxemia
|
0.240 |
Therapeutic |
RGD |
Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis.
|
25396762 |
2015 |
|
SERPINE1
|
Endotoxemia
|
0.240 |
Biomarker |
RGD |
However, EP did not reduce the elevation of plasma plasminogen activator inhibitor-1 during endotoxemia.
|
21396682 |
2011 |
|
SERPINE1
|
Chronic Obstructive Airway Disease
|
0.240 |
Biomarker |
RGD |
[Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease].
|
17651644 |
2007 |