|
SERPINA1
|
Lung diseases
|
0.600 |
GeneticVariation |
LHGDN |
In this study, an AAT polymorphism analysis in correlation with pulmonary diseases was conducted.
|
18725338 |
2008 |
|
SERPINA1
|
Lung diseases
|
0.600 |
Biomarker |
LHGDN |
AAT may be an anti-RGM host-defense factor, and anomalous AAT phenotypes or AAT deficiency may constitute risk factors for pulmonary disease due to RGM.
|
17654345 |
2007 |
|
SERPINA1
|
Lung diseases
|
0.600 |
Biomarker |
LHGDN |
Individuals with alpha(1)-AT deficiency and moderate to severe lung function impairment have lung alpha-defensins concentrations in a range known to induce cytotoxicity in vitro in the absence of normal amounts alpha(1)-AT and thus may contribute to the development of lung disease in this population.
|
16137891 |
2005 |
|
SERPINA1
|
Liver carcinoma
|
0.500 |
GeneticVariation |
LHGDN |
Our objective was to estimate the prevalence of HFE and SERPINA1 (formerly known as alpha1-antitrypsin, AAT) mutations and assess their influence on hepatocellular carcinoma development.
|
18164971 |
2008 |
|
SERPINA1
|
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation |
LHGDN |
Association of the PIM3 allele of the alpha-1-antitrypsin gene with chronic obstructive pulmonary disease.
|
15820782 |
2005 |
|
SERPINA1
|
Liver carcinoma
|
0.500 |
Biomarker |
LHGDN |
The C-terminal 26-residue peptide of serpin A1 stimulates proliferation of breast and liver cancer cells: role of protein kinase C and CD47.
|
15498560 |
2004 |
|
SERPINA1
|
Pulmonary Emphysema
|
0.500 |
GeneticVariation |
LHGDN |
MVarallo: a new M(Like) alpha 1-antitrypsin-deficient allele.
|
14639110 |
2003 |
|
SERPINA1
|
Liver diseases
|
0.400 |
GeneticVariation |
LHGDN |
The AAT gene shows significant variation, and we hypothesized that cryptic genetic variants within the AAT gene may contribute to susceptibility to liver disease.
|
17972336 |
2008 |
|
SERPINA1
|
Liver Cirrhosis
|
0.400 |
GeneticVariation |
LHGDN |
The presence of the relatively high frequency of A1AT S and HFE H63D allele carriers in Egyptian cases of HCV liver cirrhosis suggest the necessity to implement routine molecular analysis of these genes for detection of risk genotypes among affected families.
|
16802007 |
2006 |
|
SERPINA1
|
Lung Neoplasms
|
0.320 |
Biomarker |
LHGDN |
Alpha1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer risk.
|
18504338 |
2008 |
|
SERPINA1
|
Asbestosis
|
0.310 |
GeneticVariation |
LHGDN |
Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos.
|
12368052 |
2002 |
|
SERPINA1
|
Asthma
|
0.300 |
GeneticVariation |
LHGDN |
[Alpha 1 antitrypsin polymorphism associated to asthma and emphysema in a central Tunisian population].
|
18725338 |
2008 |
|
SERPINA1
|
Cystic Fibrosis
|
0.200 |
GeneticVariation |
LHGDN |
In this study, we investigated the relationship between a polymorphism (1237 G --> A) in the 3' enhancer region of the alpha-1-antitrypsin (AAT) gene and pulmonary disease severity in 320 CF patients recruited from two independent adult referral centers in Ireland, and evaluated the in vivo effect of the polymorphism on AAT levels during acute infection.
|
16617455 |
2006 |
|
SERPINA1
|
Hepatitis
|
0.140 |
GeneticVariation |
LHGDN |
Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in chronic liver diseases? Interim results of a large case-control study.
|
16819398 |
2006 |
|
SERPINA1
|
Granulomatosis with polyangiitis
|
0.080 |
Biomarker |
LHGDN |
Epidemiology of Wegener's granulomatosis: Lessons from descriptive studies and analyses of genetic and environmental risk determinants.
|
16859601 |
2006 |
|
SERPINA1
|
Alzheimer's Disease
|
0.070 |
Biomarker |
LHGDN |
HOS activity of alpha(1)-antitrypsin may curtail HO-1-dependent derangement of cerebral iron homeostasis and account for diminished HO-1 expression in AD peripheral tissues.
|
16887359 |
2006 |
|
SERPINA1
|
Hepatitis C
|
0.070 |
GeneticVariation |
LHGDN |
Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in chronic liver diseases? Interim results of a large case-control study.
|
16819398 |
2006 |
|
SERPINA1
|
Fatty Liver
|
0.060 |
GeneticVariation |
LHGDN |
Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in chronic liver diseases? Interim results of a large case-control study.
|
16819398 |
2006 |
|
SERPINA1
|
Crohn Disease
|
0.030 |
AlteredExpression |
LHGDN |
Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin.
|
18258845 |
2008 |
|
SERPINA1
|
Diabetes Mellitus
|
0.030 |
Biomarker |
LHGDN |
The additional finding of circulating antibodies against the HSP70-alpha1AT protein supported its immunogenic properties with implications for diabetes and its complications.
|
14766207 |
2004 |
|
SERPINA1
|
Dementia
|
0.030 |
Biomarker |
LHGDN |
Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia.
|
12023831 |
2002 |
|
SERPINA1
|
Prostatic Neoplasms
|
0.020 |
AlteredExpression |
LHGDN |
Alpha-1 antitrypsin (alpha1-AT) plasma levels in lung, prostate and breast cancer patients.
|
18766166 |
2008 |
|
SERPINA1
|
Infection
|
0.020 |
Biomarker |
LHGDN |
Serological proteomics of gastritis: degradation of apolipoprotein A-I and alpha1-antitrypsin is a common response to inflammation irrespective of Helicobacter pylori infection.
|
18594986 |
2008 |
|
SERPINA1
|
Infection
|
0.020 |
AlteredExpression |
LHGDN |
Helicobacter pylori infection and short-term intake of low-dose aspirin have different effects on alpha-1 antitrypsin/alpha-1 peptidase inhibitor (alpha1-PI) levels in antral mucosa and peripheral blood.
|
18609127 |
2008 |
|
SERPINA1
|
insulinoma
|
0.020 |
AlteredExpression |
LHGDN |
Serpin peptidase inhibitor clade A member 1 (SERPINA1; alpha-1-antitrypsin) expression, identified as up-regulated in malignant insulinomas, was also evaluated by immunohistochemistry.
|
17855650 |
2007 |