Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity 		1.000 Biomarker RGD Role of adipogenic and thermogenic genes in susceptibility or resistance to develop diet-induced obesity in rats. 18457007

2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker RGD Oral intake of rosiglitazone promotes a central antihypertensive effect via upregulation of peroxisome proliferator-activated receptor-gamma and alleviation of oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats. 20404217

2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker RGD Cardioprotective mechanism of telmisartan via PPAR-gamma-eNOS pathway in dahl salt-sensitive hypertensive rats. 18437150

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker RGD Impaired expression of PPAR gamma protein contributes to the exaggerated growth of vascular smooth muscle cells in spontaneously hypertensive rats. 15970297

2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 Biomarker RGD In the present study, we investigated the effect and molecular mechanism of the PPARgamma agonist, pioglitazone, on the progression of diabetic nephropathy in type 2 diabetic rats. 18388116

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0021368
Disease: Inflammation
Inflammation 		0.520 Biomarker RGD Since peroxisome proliferator-activated receptor gamma (PPARgamma) acts as a regulator of CNS inflammation and a powerful pharmacological target for counteracting CNS diseases, we investigated the role of the PPARgamma agonist, rosiglitazone, in the modulation of CD40 expression and in the pathological processes of inflammation after SE. 18455351

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0021368
Disease: Inflammation
Inflammation 		0.520 Biomarker RGD Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. 18479673

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD Tissue-specific expression of PPAR mRNAs in diabetic rats and divergent effects of cilostazol. 18641696

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Therapeutic RGD Ciglitazone, a peroxisome proliferator-activated receptor gamma inducer, ameliorates renal preglomerular production and activity of angiotensin II and thromboxane A2 in glycerol-induced acute renal failure. 17494862

2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.500 Biomarker RGD Decreased expression of peroxisome proliferator-activated receptor gamma in endotoxin-induced acute lung injury. 16083301

2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.500 Therapeutic RGD Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. 11318962

2001
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.400 Biomarker RGD Peroxisome proliferator activated receptor-gamma in pathogenesis of experimental fatty liver disease. 15112352

2004
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.320 Biomarker RGD [Effects of peroxisome proliferators-activated receptor-gamma on the function of the vital organs in rats with pancreatitis]. 18583255

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.300 Biomarker RGD Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers. 18712722

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.300 Biomarker RGD Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers. 18712722

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.300 Therapeutic RGD Because ligands for peroxisome proliferator-activated receptor gamma have beneficial effects on the arterial wall in atherosclerosis, via an antiinflammatory mechanism, we investigated whether long-term pioglitazone (Pio) treatment protects against another form of vascular wall disease, arteriosclerosis. 15967870

2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 Biomarker RGD Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats. 16183630

2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.270 Biomarker RGD In rat lungs, IUGR impairs alveolarization in conjunction with altered expression of peroxisome proliferator-activated receptor gamma (PPARγ). 21425435

2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0206081
Disease: Hyperandrogenism
Hyperandrogenism 		0.240 Biomarker RGD Peroxisome proliferator-activated receptor gamma and early folliculogenesis during an acute hyperandrogenism condition. 20813360

2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.220 Biomarker RGD Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation. 19221220

2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.220 Biomarker RGD Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. 18973594

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.220 Biomarker RGD Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain. 18378216

2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.210 Biomarker RGD Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. 21641970

2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.210 Biomarker RGD Peroxisome proliferator activated receptor-gamma in pathogenesis of experimental fatty liver disease. 15112352

2004
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C1868773
Disease: Diabetic encephalopathy
Diabetic encephalopathy 		0.200 Therapeutic RGD Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. 24291733

2014