Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 Biomarker RGD Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. 17203219

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.500 Biomarker RGD Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. 15930288

2005
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.300 Biomarker RGD Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. 15930288

2005
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.220 Biomarker RGD Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. 17203219

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.220 Biomarker RGD Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. 17203219

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.220 Biomarker RGD Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. 17203219

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0027697
Disease: Nephritis
Nephritis 		0.200 Therapeutic RGD [Effects of prednisone on renal FAK and Pyk2 expressions in rats with adriamycin- induced nephritis]. 25176084

2014
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Biomarker RGD Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease. 21068519

2010
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0022116
Disease: Ischemia
Ischemia 		0.200 Biomarker RGD Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury. 17620366

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury. 17620366

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0041948
Disease: Uremia
Uremia 		0.200 Biomarker RGD A role for enhanced integrin and FAK expression in uremia-induced parathyroid hyperplasia. 17514628

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0162770
Disease: Right Ventricular Hypertrophy
Right Ventricular Hypertrophy 		0.200 Biomarker RGD Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. 17913382

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C2676033
Disease: Hepatoblastoma Caused By Somatic Mutation
Hepatoblastoma Caused By Somatic Mutation 		0.200 Biomarker RGD Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. 17203219

2007
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.200 Biomarker RGD Relationship between focal adhesion kinase and hepatic stellate cell proliferation during rat hepatic fibrogenesis. 15378782

2004
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Biomarker RGD Focal adhesion kinase (FAK) and focal adhesion kinase-related nonkinase (FRNK) are likely involved in mechanical signaling during hypertension. 12732587

2003
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0149721
Disease: Left Ventricular Hypertrophy
Left Ventricular Hypertrophy 		0.200 Biomarker RGD Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium. 12732587

2003