Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Therapeutic RGD CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. 29777699

2018

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Therapeutic RGD "Xiusanzhen" can regulate the expression of hippocampal Bcl-2 and Bax proteins in AD rats, which may contribute to its clinical effect in relieving AD, and the therapeutic effect depends on the integrity of the olfactory nerve pathway. 21585051

2011

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Biomarker RGD [Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease]. 17639989

2007

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.520 Biomarker RGD Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain. 16265626

2005

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD [Effects of hydrogen-rich saline on endoplasmic reticulum stress during myocardial ischemia-reperfusion in rats]. 25547710

2014

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Therapeutic RGD NMDA and AMPA receptor mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rat: ameliorating effects of curcumin. 23267840

2013

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.500 Therapeutic RGD [Effects of BNP preconditioning on myocardial cell apoptosis and expressions of bcl-2 and Bax during myocardial ischemia-reperfusion injury in rats]. 21223820

2010

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.500 Therapeutic RGD N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins. 20037173

2010

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Biomarker RGD The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats. 18991018

2009

Entrez Id: 581
Gene Symbol: BAX
BAX
Diabetes Mellitus, Non-Insulin-Dependent
0.240 Therapeutic RGD Regulation of signaling molecules associated with insulin action, insulin secretion and pancreatic β-cell mass in the hypoglycemic effects of Korean red ginseng in Goto-Kakizaki rats. 22543177

2012

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.220 Therapeutic RGD Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs. 29746994

2018

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0023267
Disease: Fibroid Tumor
Fibroid Tumor
0.220 Therapeutic RGD Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat. 23789224

2013

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation
0.220 Therapeutic RGD Antenatal supplementation of taurine for protection of fetal rat brain with intrauterine growth restriction from injury by reducing neuronal apoptosis. 22932950

2012

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.220 Therapeutic RGD Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats. 20065158

2010

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.220 Therapeutic RGD Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure. 18097624

2008

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0018801
Disease: Heart failure
Heart failure
0.210 Therapeutic RGD Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs. 29746994

2018

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.210 Therapeutic RGD Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. 27131981

2017

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.210 Biomarker RGD Comparison between axonal and retinal ganglion cell gene expression in various optic nerve injuries including glaucoma. 24357921

2013

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.210 Therapeutic RGD The effect of the Ginkgo biloba extract in the expression of Bax, Bcl-2 and bone mineral content of Wistar rats with glucocorticoid-induced osteoporosis. 22648569

2013

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Therapeutic RGD Post-treatment of Bax-inhibiting peptide reduces neuronal death and behavioral deficits following global cerebral ischemia. 21167243

2011

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.210 Therapeutic RGD Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium. 21308783

2011

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0018801
Disease: Heart failure
Heart failure
0.210 Therapeutic RGD Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure. 18097624

2008

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain
0.200 Therapeutic RGD Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway. 29635023

2018

Entrez Id: 581
Gene Symbol: BAX
BAX
CUI: C3665419
Disease: intracranial glioma
intracranial glioma
0.200 Therapeutic RGD NFAT-1 hyper-activation by methionine enkephalin (MENK) significantly induces cell apoptosis of rats C6 glioma in vivo and in vitro. 29324390

2018