Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human [Correlation of angiotensin-converting enzyme 2 gene polymorphism with antihypertensive effects of benazepril]. 20559404

2010
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic CTD_human [Correlation of angiotensin-converting enzyme 2 gene polymorphism with antihypertensive effects of benazepril]. 20559404

2010
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2. 19221212

2009
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic CTD_human Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2. 19221212

2009
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human We conclude that the ACE2 T allele confers a high risk for hypertension and reduced antihypertensive response to ACE inhibitors. 17473847

2007
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic CTD_human We conclude that the ACE2 T allele confers a high risk for hypertension and reduced antihypertensive response to ACE inhibitors. 17473847

2007
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Therapeutic CTD_human Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. 15833808

2005
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker CTD_human Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. 15833808

2005
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.400 Therapeutic CTD_human To explore the renoprotective effects of ACE2 overexpression, ACE inhibition (ACEI) or both on diabetic nephropathy and the potential mechanisms involved, 50 Wistar rats were randomly divided into a normal group that received an injection of sodium citrate buffer and a diabetic model group that received an injection of 60 mg/kg streptozotocin. 20844835

2011
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.350 Therapeutic CTD_human Because ACE2 deficiency promoted AAA formation in AngII-infused mice, we determined whether ACE2 activation suppressed AAAs. 25301841

2014
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0017667
Disease: Nodular glomerulosclerosis
Nodular glomerulosclerosis 		0.310 Therapeutic CTD_human Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition. 20844835

2011
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C4552766
Disease: Miscarriage
Miscarriage 		0.310 Biomarker CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642

2008
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0553980
Disease: Endomyocardial Fibrosis
Endomyocardial Fibrosis 		0.300 Biomarker CTD_human Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2. 19221212

2009
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0000786
Disease: Spontaneous abortion
Spontaneous abortion 		0.300 Biomarker CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642

2008
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0000822
Disease: Abortion, Tubal
Abortion, Tubal 		0.300 Biomarker CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642

2008
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C3830362
Disease: Early Pregnancy Loss
Early Pregnancy Loss 		0.300 Biomarker CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642

2008