Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.570 Biomarker CTD_human Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. 21284947

2011
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.570 Biomarker CTD_human This study examined telomere biology in heart/muscle-specific manganese superoxide dismutase-deficient mice (H/M-SOD2(-/-)), which develop progressive congestive heart failure and exhibit pathology typical of dilated cardiomyopathy. 21195081

2011
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.570 Biomarker CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815

2010
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.570 Biomarker CTD_human Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy. 16155095

2005
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.570 Biomarker CTD_human Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium. 16105639

2005
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.550 Biomarker CTD_human Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies. 25101153

2014
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.550 Biomarker CTD_human Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice. 21195081

2011
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.550 Biomarker CTD_human Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. 21284947

2011
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.550 Biomarker CTD_human Circulating progenitor cells are increased in newly diagnosed untreated hypertensive patients with arterial stiffening but normal carotid intima-media thickness. 21593737

2011
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.550 Biomarker CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815

2010
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.550 Biomarker CTD_human Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium. 16105639

2005
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0018801
Disease: Heart failure
Heart failure 		0.550 Biomarker CTD_human Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy. 16155095

2005
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.550 Biomarker CTD_human Gene transfer of endothelial NO synthase and manganese superoxide dismutase on arterial vascular cell adhesion molecule-1 expression and superoxide production in deoxycorticosterone acetate-salt hypertension. 11834524

2002
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.520 Therapeutic CTD_human Role of adenosine in delayed preconditioning of myocardium. 12160945

2002
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.510 Biomarker CTD_human Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice. 21195081

2011
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.510 Biomarker CTD_human Differential regulation of the superoxide dismutase family in experimental aortic aneurysms and rat aortic explants. 17196988

2007
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.510 Biomarker CTD_human Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy. 16155095

2005
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0035222
Disease: Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult 		0.500 Biomarker CTD_human MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. 25070658

2014
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice. 23090186

2013
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Therapeutic CTD_human Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice. 23090186

2013
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker CTD_human Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats. 23743330

2013
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Therapeutic CTD_human Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats. 23743330

2013
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Therapeutic CTD_human Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke. 21940958

2011
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker CTD_human Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke. 21940958

2011
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Therapeutic CTD_human Increased superoxide formation induced by irradiation preconditioning triggers kidney resistance to ischemia-reperfusion injury in mice. 19193722

2009