Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia 		0.400 Biomarker RGD These studies demonstrate in a variety of rodent models that systemic delivery of Kir6.2/SUR-1-selective KCOs enhance the glucose counterregulatory response to insulin-induced hypoglycemia. 18776135

2008
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.230 Therapeutic RGD Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage. 24114458

2013
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0018790
Disease: Cardiac Arrest
Cardiac Arrest 		0.210 Therapeutic RGD Glibenclamide Improves Survival and Neurologic Outcome After Cardiac Arrest in Rats. 26010685

2015
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.210 Biomarker RGD Abcc8 (Sur1; subunit of ATP-sensitive potassium (K(ATP)) channel) was significantly down-regulated at 10 days post SE. 22050960

2011
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.210 Biomarker RGD Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. 17285300

2007
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0600228
Disease: Cardiopulmonary Arrest
Cardiopulmonary Arrest 		0.200 Therapeutic RGD Glibenclamide Improves Survival and Neurologic Outcome After Cardiac Arrest in Rats. 26010685

2015
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.200 Therapeutic RGD Protective effect of treatment with low-dose gliclazide in a model of middle cerebral artery occlusion and reperfusion in rats. 24602692

2014
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.200 Therapeutic RGD Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. 23149556

2013
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C1527311
Disease: Brain Edema
Brain Edema 		0.200 Therapeutic RGD Inhibition of SUR1 decreases the vascular permeability of cerebral metastases. 23633925

2013
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy 		0.200 Biomarker RGD Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. 21907492

2011
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0027540
Disease: Necrosis
Necrosis 		0.200 Biomarker RGD SUR1 expression was upregulated in capillaries and neurons surrounding necrotic lesions. 17657312

2007
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.200 Biomarker RGD The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats. 18021373

2007
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C1527311
Disease: Brain Edema
Brain Edema 		0.200 Biomarker RGD Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke. 16550187

2006
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders 		0.200 Biomarker RGD Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease? 15857625

2005