Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 Biomarker RGD The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. 18648551

2008
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0243026
Disease: Sepsis
Sepsis 		0.290 ModifyingMutation RGD Neutrophil C5a receptor and the outcome in a rat model of sepsis. 12897064

2003
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0004096
Disease: Asthma
Asthma 		0.270 Biomarker RGD Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation. 17544263

2007
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.240 Biomarker RGD To determine the contribution of C5a to the pathology displayed by this model of ALS, rats were administered an orally active, selective C5aR antagonist (PMX205; 1 mg/kg/day, oral). 19050293

2008
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.210 Biomarker RGD cDNA cloning and characterization of rat C5a anaphylatoxin receptor. 9272704

1997
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0028754
Disease: Obesity
Obesity 		0.200 Therapeutic RGD These studies reveal important new links between complement signaling and metabolism, highlight new complement functions on adipocytes and in adipose tissue, demonstrate how aberrant immune responses may exacerbate obesity and metabolic dysfunction, and show that targeting C3aR or C5aR with antagonists is a new strategy for treating metabolic dysfunction. 23118029

2013
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.200 Biomarker RGD Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation. 17544263

2007
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0035222
Disease: Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult 		0.200 Therapeutic RGD Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. 16782534

2006
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0026766
Disease: Multiple Organ Failure
Multiple Organ Failure 		0.200 Biomarker RGD Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm. 14718840

2004
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. 15158333

2004
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. 15159277

2004
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0040053
Disease: Thrombosis
Thrombosis 		0.200 Biomarker RGD The role of C5a in the development of thrombotic glomerulonephritis in rats. 11422211

2001
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
CUI: C0027947
Disease: Neutropenia
Neutropenia 		0.200 Biomarker RGD Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat. 10516626

1999