Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0740394
Disease: Hyperuricemia
Hyperuricemia 		0.600 Therapeutic RGD Cd exposure induced hyperuricemia with renal XOR hyperactivity and UA excretion dysfunction in rats. 22690247

2012
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Therapeutic RGD Protective effect of endogenous hydrogen sulfide against oxidative stress in gastric ischemia-reperfusion injury. 23403765

2013
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0026848
Disease: Myopathy
Myopathy 		0.300 Therapeutic RGD Lipid peroxidation and changes in cytochrome c oxidase and xanthine oxidase activity in organophosphorus anticholinesterase induced myopathy. 9789800

1999
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.270 Therapeutic RGD Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats. 23746952

2013
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.270 Biomarker RGD Xanthine oxidase activity in the dexamethasone-induced hypertensive rat. 12826072

2003
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0028754
Disease: Obesity
Obesity 		0.220 Therapeutic RGD This study was conducted to examine the effect of an 18% casein diet supplemented with 0.5% nicotinamide on the activity of oxidoreductase and its two enzyme forms, xanthine dehydrogenase and xanthine oxidase, in kidney, heart and liver of female obese Zucker rats that spontaneously develop glomerulosclerosis, cardiomegaly and fatty liver. 7616299

1995
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.220 Biomarker RGD Malignant transformation-linked imbalance: decreased xanthine oxidase activity in hepatomas. 179860

1975
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0243026
Disease: Sepsis
Sepsis 		0.210 Therapeutic RGD [The protective effects of carbachol on visceral ischemia-induced lipid peroxidation injury in rats with sepsis]. 19751566

2009
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.210 Biomarker RGD Taking into account the ability of alpha-amylase to hydrolyze the internal alpha-1,4 linkages of polysaccharides, we wanted to elucidate the involvement of alpha-amylase in XDH/XOD mobilization from the gastrointestinal endothelial cell surface and the relevance of the ascitic fluid (AF) as the source of alpha-amylase in experimental acute pancreatitis. 14728722

2004
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0029531
Disease: Other cataract
Other cataract 		0.200 Therapeutic RGD The effects of Nigella sativa oil, thymoquinone, propolis, and caffeic acid phenethyl ester on radiation-induced cataract. 25860848

2016
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0151942
Disease: Arterial thrombosis
Arterial thrombosis 		0.200 Therapeutic RGD Role of xanthine oxidoreductase in the anti-thrombotic effects of nitrite in rats in vivo. 26374946

2016
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0020500
Disease: Hyperoxaluria
Hyperoxaluria 		0.200 Biomarker RGD High Sodium-Induced Oxidative Stress and Poor Anticrystallization Defense Aggravate Calcium Oxalate Crystal Formation in Rat Hyperoxaluric Kidneys. 26241473

2015
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0033141
Disease: Cardiomyopathies, Primary
Cardiomyopathies, Primary 		0.200 Therapeutic RGD Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system. 25889404

2015
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0036529
Disease: Myocardial Diseases, Secondary
Myocardial Diseases, Secondary 		0.200 Therapeutic RGD Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system. 25889404

2015
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.200 Therapeutic RGD Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system. 25889404

2015
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0018129
Disease: Graft Rejection
Graft Rejection 		0.200 Therapeutic RGD Remote ischemic preconditioning differentially affects NADPH oxidase isoforms during hepatic ischemia-reperfusion. 24768926

2014
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0033141
Disease: Cardiomyopathies, Primary
Cardiomyopathies, Primary 		0.200 Therapeutic RGD The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy. 23751350

2013
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0036529
Disease: Myocardial Diseases, Secondary
Myocardial Diseases, Secondary 		0.200 Therapeutic RGD The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy. 23751350

2013
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies 		0.200 Therapeutic RGD Multiple antioxidants improve cardiac complications and inhibit cardiac cell death in streptozotocin-induced diabetic rats. 23843977

2013
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.200 Therapeutic RGD The xanthine oxidase inhibitor oxypurinol reduces cancer cachexia-induced cardiomyopathy. 23751350

2013
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.200 Therapeutic RGD Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. 22302365

2012
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.200 Therapeutic RGD Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. 22622455

2012
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.200 Therapeutic RGD Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy. 22350467

2012
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.200 Therapeutic RGD Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. 22571266

2012
Entrez Id: 7498
Gene Symbol: XDH
XDH
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.200 Therapeutic RGD Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion. 19628223

2010