Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.520 Biomarker RGD In cholestasis, prolactin increased mrp3 manifestation of only in the distal renal tubules. 23486593

2013
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.520 Biomarker RGD Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats. 18096675

2008
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.270 Biomarker RGD Kcna3, Kcnn4, Kcnrg and Kcnj11 potassium channel mRNA expression reached peak values at the end of DEN treatment, while Scn2a1 sodium channel, Trpc6 calcium channel and Abcc3 transporter mRNA expression reached their highest levels in the presence of HCC (18 weeks). 25842354

2015
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.240 Biomarker RGD Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development. 25842354

2015
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.210 Biomarker RGD Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development. 25842354

2015
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0022350
Disease: Jaundice, Chronic Idiopathic
Jaundice, Chronic Idiopathic 		0.210 Biomarker RGD Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. 14731123

2004
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.200 Biomarker RGD Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development. 25842354

2015
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C2676033
Disease: Hepatoblastoma Caused By Somatic Mutation
Hepatoblastoma Caused By Somatic Mutation 		0.200 Biomarker RGD Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development. 25842354

2015
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0008043
Disease: Chiari-Frommel Syndrome
Chiari-Frommel Syndrome 		0.200 Biomarker RGD Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia. 23486593

2013
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0020514
Disease: Hyperprolactinemia
Hyperprolactinemia 		0.200 Biomarker RGD Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia. 23486593

2013
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C2750440
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. 22112382

2012
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Biomarker RGD Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. 22112382

2012
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C3150651
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2 		0.200 Biomarker RGD Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. 22112382

2012
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver. 20487213

2010
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.200 ModifyingMutation RGD Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats. 17855625

2008
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.200 Biomarker RGD Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. 17640958

2007
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.200 Biomarker RGD Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. 17640958

2007
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.200 Biomarker RGD Protein expression of Pgp, MRP2, and MRP3 were reduced by more than 40% (p < 0.01) in CRF rats, whereas Oatp2 and Oatp3 expression remained unchanged. 17135344

2007
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5 		0.200 Biomarker RGD Down-regulation of intestinal drug transporters in chronic renal failure in rats. 17135344

2007
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0020433
Disease: Hyperbilirubinemia
Hyperbilirubinemia 		0.200 Biomarker RGD These results suggest that hepatic Mrp3 and Ho-1 may contribute to tienilic acid-enhanced hyperbilirubinemia in EHBR by inducing increased bilirubin transport from the liver into the blood stream, preceded by potentiation of bilirubin formation in the liver. 16543292

2006
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0020435
Disease: Hyperbilirubinemia, Hereditary
Hyperbilirubinemia, Hereditary 		0.200 Biomarker RGD Tienilic acid enhances hyperbilirubinemia in Eisai hyperbilirubinuria rats through hepatic multidrug resistance-associated protein 3 and heme oxygenase-1 induction. 16543292

2006