Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0027873
Disease: Neuromyelitis Optica
Neuromyelitis Optica 		0.240 ModifyingMutation RGD Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. 28212662

2017
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.240 Biomarker RGD Loss of CD59 in the AMI lesions was observed in association with deposits of MAC from day one onward. 7515561

1994
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.210 Biomarker RGD Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy. 12453906

2002
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0042165
Disease: Anterior uveitis
Anterior uveitis 		0.200 Biomarker RGD Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). 16751365

2006
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0027720
Disease: Nephrosis
Nephrosis 		0.200 Biomarker RGD Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. 15843577

2005
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0267941
Disease: Pancreatitis, Acute Necrotizing
Pancreatitis, Acute Necrotizing 		0.200 ModifyingMutation RGD Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis. 16425382

2005
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.200 Biomarker RGD Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model. 12909127

2003
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0023896
Disease: Alcoholic Liver Diseases
Alcoholic Liver Diseases 		0.200 Biomarker RGD Activation of complement components and reduced regulator expression in alcohol-induced liver injury in the rat. 12483994

2002
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0027814
Disease: Neuritis, Autoimmune, Experimental
Neuritis, Autoimmune, Experimental 		0.200 Biomarker RGD The expression of CD59 in experimental allergic neuritis. 10450801

1999
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa. 10530491

1999
Entrez Id: 966
Gene Symbol: CD59
CD59
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.200 Biomarker RGD To assess the role of CD59 in complement-mediated glomerular injury, 6D1 was tested in a model of experimental glomerulonephritis induced by a lectin and its antibodies. 7523753

1994