Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker CTD_human By the means of immunohistochemistry, COX-2, vascular endothelial growth factor-C (VEGF-C) and D2-40 were examined in the tissue samples of primary tumors from 94 patients underwent surgical resections for breast cancer from November 1998 to March 2002.Eighty-three patients were followed-up. 18509974

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker CTD_human This data suggests that COX-2 may be an important target for breast cancer treatment. 18498876

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker CTD_human We used a nude mouse xenograft model to determine the effects of COX-2 inhibition in breast cancer. 17285134

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker CTD_human Clinical and animal studies have revealed that cyclooxygenase-2 (COX-2) expression is associated with a risk of breast cancer. 16870006

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker CTD_human To determine whether COX-2 induces drug resistance, plasmids encoding the COX-2 gene were stably transfected into ERalpha-positive MCF-7 human breast cancer cells (MCF-7/COX-2). 16127422

2005