Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Elevated pulmonary arterial pressure in Zucker diabetic fatty rats. 30689673

2019
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat. 29743445

2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. 25222487

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy. 24263156

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Evaluation of 29 SNPs (P < 1 × 10(-5)) in an additional 971 severely obese children and 1,990 controls identified 4 new loci associated with severe obesity (LEPR, PRKCH, PACS1 and RMST). 23563609

2013
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity. 22276206

2012
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. 20567778

2010
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human The role of osteopontin in d-galactosamine-induced liver injury in genetically obese mice. 19913045

2010
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human A single family has been described in which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset obesity has not been systematically examined. 17229951

2007
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human "Estrone treatment dissociates primary versus secondary consequences of ""diabetes"" (db) gene expression in mice." 3519326

1986